Analysis of the complete DNA sequence of murine cytomegalovirus

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J. Virol., Dec 1996, 8833-8849, Vol 70, No. 12
Copyright © 1996, American Society for Microbiology

Analysis of the complete DNA sequence of murine cytomegalovirus

WD Rawlinson, HE Farrell and BG Barrell
Laboratory of Molecular Biology, Cambridge, United Kingdom. WDR@westmed.wh.su.edu.au

The complete DNA sequence of the Smith strain of murine cytomegalovirus (MCMV) was determined from virion DNA by using a whole-genome shotgun approach. The genome has an overall G+C content of 58.7%, consists of 230,278 bp, and is arranged as a single unique sequence with short (31- bp) terminal direct repeats and several short internal repeats. Significant similarity to the genome of the sequenced human cytomegalovirus (HCMV) strain AD169 is evident, particularly for 78 open reading frames encoded by the central part of the genome. There is a very similar distribution of G+C content across the two genomes. Sequences toward the ends of the MCMV genome encode tandem arrays of homologous glycoproteins (gps) arranged as two gene families. The left end encodes 15 gps that represent one family, and the right end encodes a different family of 11 gps. A homolog (m144) of cellular major histocompatibility complex (MHC) class I genes is located at the end of the genome opposite the HCMV MHC class I homolog (UL18). G protein- coupled receptor (GCR) homologs (M33 and M78) occur in positions congruent with two (UL33 and UL78) of the four putative HCMV GCR homologs. Counterparts of all of the known enzyme homologs in HCMV are present in the MCMV genome, including the phosphotransferase gene (M97), whose product phosphorylates ganciclovir in HCMV-infected cells, and the assembly protein (M80).

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Davison, A. J., Dolan, A., Akter, P., Addison, C., Dargan, D. J., Alcendor, D. J., McGeoch, D. J., Hayward, G. S. (2003). The human cytomegalovirus genome revisited: comparison with the chimpanzee cytomegalovirus genome. J. Gen. Virol. 84: 17-28 [Abstract] [Full Text]
Tang, Q., Maul, G. G. (2002). Mouse Cytomegalovirus Immediate-Early Protein 1 Binds with Host Cell Repressors To Relieve Suppressive Effects on Viral Transcription and Replication during Lytic Infection. J. Virol. 77: 1357-1367 [Abstract] [Full Text]
Gribaudo, G., Riera, L., Rudge, T. L., Caposio, P., Johnson, L. F., Landolfo, S. (2002). Human cytomegalovirus infection induces cellular thymidylate synthase gene expression in quiescent fibroblasts. J. Gen. Virol. 83: 2983-2993 [Abstract] [Full Text]
Wagner, M., Gutermann, A., Podlech, J., Reddehase, M. J., Koszinowski, U. H. (2002). Major Histocompatibility Complex Class I Allele-specific Cooperative and Competitive Interactions between Immune Evasion Proteins of Cytomegalovirus. J. Exp. Med. 196: 805-816 [Abstract] [Full Text]
Chang, W. L. W., Tarantal, A. F., Zhou, S. S., Borowsky, A. D., Barry, P. A. (2002). A Recombinant Rhesus Cytomegalovirus Expressing Enhanced Green Fluorescent Protein Retains the Wild-Type Phenotype and Pathogenicity in Fetal Macaques. J. Virol. 76: 9493-9504 [Abstract] [Full Text]
Muranyi, W., Haas, J., Wagner, M., Krohne, G., Koszinowski, U. H. (2002). Cytomegalovirus Recruitment of Cellular Kinases to Dissolve the Nuclear Lamina. Science 297: 854-857 [Abstract] [Full Text]
Gold, M. C., Munks, M. W., Wagner, M., Koszinowski, U. H., Hill, A. B., Fling, S. P. (2002). The Murine Cytomegalovirus Immunomodulatory Gene m152 Prevents Recognition of Infected Cells by M45-Specific CTL But Does Not Alter the Immunodominance of the M45-Specific CD8 T Cell Response In Vivo. J. Immunol. 169: 359-365 [Abstract] [Full Text]
Smith, H. R. C., Heusel, J. W., Mehta, I. K., Kim, S., Dorner, B. G., Naidenko, O. V., Iizuka, K., Furukawa, H., Beckman, D. L., Pingel, J. T., Scalzo, A. A., Fremont, D. H., Yokoyama, W. M. (2002). Recognition of a virus-encoded ligand by a natural killer cell activation receptor. Proc. Natl. Acad. Sci. USA 99: 8826-8831 [Abstract] [Full Text]
Adair, R., Douglas, E. R., Maclean, J. B., Graham, S. Y., Aitken, J. D., Jamieson, F. E., Dargan, D. J. (2002). The products of human cytomegalovirus genes UL23, UL24, UL43 and US22 are tegument components. J. Gen. Virol. 83: 1315-1324 [Abstract] [Full Text]
Holtappels, R., Grzimek, N. K. A., Simon, C. O., Thomas, D., Dreis, D., Reddehase, M. J. (2002). Processing and Presentation of Murine Cytomegalovirus pORFm164-Derived Peptide in Fibroblasts in the Face of All Viral Immunosubversive Early Gene Functions. J. Virol. 76: 6044-6053 [Abstract] [Full Text]
Morello, C. S., Ye, M., Spector, D. H. (2002). Development of a Vaccine against Murine Cytomegalovirus (MCMV), Consisting of Plasmid DNA and Formalin-Inactivated MCMV, That Provides Long-Term, Complete Protection against Viral Replication. J. Virol. 76: 4822-4835 [Abstract] [Full Text]
Stamminger, T., Gstaiger, M., Weinzierl, K., Lorz, K., Winkler, M., Schaffner, W. (2002). Open Reading Frame UL26 of Human Cytomegalovirus Encodes a Novel Tegument Protein That Contains a Strong Transcriptional Activation Domain. J. Virol. 76: 4836-4847 [Abstract] [Full Text]
Liu, Y., Biegalke, B. J. (2002). The Human Cytomegalovirus UL35 Gene Encodes Two Proteins with Different Functions. J. Virol. 76: 2460-2468 [Abstract] [Full Text]
Holtappels, R., Grzimek, N. K. A., Thomas, D., Reddehase, M. J. (2002). Early gene m18, a novel player in the immune response to murine cytomegalovirus. J. Gen. Virol. 83: 311-316 [Abstract] [Full Text]
Gruijthuijsen, Y. K., Casarosa, P., Kaptein, S. J. F., Broers, J. L. V., Leurs, R., Bruggeman, C. A., Smit, M. J., Vink, C. (2002). The Rat Cytomegalovirus R33-Encoded G Protein-Coupled Receptor Signals in a Constitutive Fashion. J. Virol. 76: 1328-1338 [Abstract] [Full Text]
Spaderna, S., Blessing, H., Bogner, E., Britt, W., Mach, M. (2002). Identification of Glycoprotein gpTRL10 as a Structural Component of Human Cytomegalovirus. J. Virol. 76: 1450-1460 [Abstract] [Full Text]
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Holtappels, R., Thomas, D., Podlech, J., Reddehase, M. J. (2002). Two Antigenic Peptides from Genes m123 and m164 of Murine Cytomegalovirus Quantitatively Dominate CD8 T-Cell Memory in the H-2d Haplotype. J. Virol. 76: 151-164 [Abstract] [Full Text]

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