This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Borrow, P Articles by Oldstone, M B Search for Related Content PubMed PubMed Citation Articles by Borrow, P Articles by Oldstone, M B

 Previous Article  |  Next Article 

J Virol. 1994 September; 68(9): 6103-6110

Virus-specific CD8+ cytotoxic T-lymphocyte activity associated with control of viremia in primary human immunodeficiency virus type 1 infection.

Department of Neuropharmacology, Scripps Research Institute, La Jolla, California 92037.

ABSTRACT

Human immunodeficiency virus type 1 (HIV-1) Env-, Gag-, Pol-, Nef-, and Tat-specific cytotoxic T-lymphocyte (CTL) activities were quantitated temporally in five patients with symptomatic primary HIV-1 infection. A dominant CD8(+)-mediated, major histocompatibility complex class I-restricted CTL response to the HIV-1 envelope glycoprotein, gp160, was noted in four of the five patients studied. The level of HIV-1-specific CTL activity in the five patients paralleled the efficiency of control of primary viremia. Patients who mounted strong gp160-specific CTL responses showed rapid reduction of acute plasma viremia and antigenemia, while in contrast, primary viremia and antigenemia were poorly controlled in patients in whom virus-specific CTL activity was low or undetectable. These results suggest that HIV-1-specific CTL activity is a major component of the host immune response associated with the control of virus replication following primary HIV-1 infection and have important implications for the design of antiviral vaccines.

This article has been cited by other articles:

• Kawada, M., Tsukamoto, T., Yamamoto, H., Iwamoto, N., Kurihara, K., Takeda, A., Moriya, C., Takeuchi, H., Akari, H., Matano, T. (2008). Gag-Specific Cytotoxic T-Lymphocyte-Based Control of Primary Simian Immunodeficiency Virus Replication in a Vaccine Trial. J. Virol. 82: 10199-10206 [Abstract] [Full Text]  
• Stevceva, L., Yoon, V., Carville, A., Pacheco, B., Santosuosso, M., Korioth-Schmitz, B., Mansfield, K., Poznansky, M. C. (2008). The Efficacy of T Cell-Mediated Immune Responses Is Reduced by the Envelope Protein of the Chimeric HIV-1/SIV-KB9 Virus In Vivo. J. Immunol. 181: 5510-5521 [Abstract] [Full Text]  
• Brumme, Z. L., Brumme, C. J., Carlson, J., Streeck, H., John, M., Eichbaum, Q., Block, B. L., Baker, B., Kadie, C., Markowitz, M., Jessen, H., Kelleher, A. D., Rosenberg, E., Kaldor, J., Yuki, Y., Carrington, M., Allen, T. M., Mallal, S., Altfeld, M., Heckerman, D., Walker, B. D. (2008). Marked Epitope- and Allele-Specific Differences in Rates of Mutation in Human Immunodeficiency Type 1 (HIV-1) Gag, Pol, and Nef Cytotoxic T-Lymphocyte Epitopes in Acute/Early HIV-1 Infection. J. Virol. 82: 9216-9227 [Abstract] [Full Text]  
• Cox, K. S., Clair, J. H., Prokop, M. T., Sykes, K. J., Dubey, S. A., Shiver, J. W., Robertson, M. N., Casimiro, D. R. (2008). DNA gag/Adenovirus Type 5 (Ad5) gag and Ad5 gag/Ad5 gag Vaccines Induce Distinct T-Cell Response Profiles. J. Virol. 82: 8161-8171 [Abstract] [Full Text]  
• Kim, E.-Y., Veazey, R. S., Zahn, R., McEvers, K. J., Baumeister, S. H. C., Foster, G. J., Rett, M. D., Newberg, M. H., Kuroda, M. J., Rieber, E. P., Piatak, M. Jr., Lifson, J. D., Letvin, N. L., Wolinsky, S. M., Schmitz, J. E. (2008). Contribution of CD8+ T Cells to Containment of Viral Replication and Emergence of Mutations in Mamu-A*01-Restricted Epitopes in Simian Immunodeficiency Virus-Infected Rhesus Monkeys. J. Virol. 82: 5631-5635 [Abstract] [Full Text]  
• Veazey, R. S., Acierno, P. M., McEvers, K. J., Baumeister, S. H. C., Foster, G. J., Rett, M. D., Newberg, M. H., Kuroda, M. J., Williams, K., Kim, E.-Y., Wolinsky, S. M., Rieber, E. P., Piatak, M. Jr., Lifson, J. D., Montefiori, D. C., Brown, C. R., Hirsch, V. M., Schmitz, J. E. (2008). Increased Loss of CCR5+ CD45RA- CD4+ T Cells in CD8+ Lymphocyte-Depleted Simian Immunodeficiency Virus-Infected Rhesus Monkeys. J. Virol. 82: 5618-5630 [Abstract] [Full Text]  
• Schneidewind, A., Brockman, M. A., Sidney, J., Wang, Y. E., Chen, H., Suscovich, T. J., Li, B., Adam, R. I., Allgaier, R. L., Mothe, B. R., Kuntzen, T., Oniangue-Ndza, C., Trocha, A., Yu, X. G., Brander, C., Sette, A., Walker, B. D., Allen, T. M. (2008). Structural and Functional Constraints Limit Options for Cytotoxic T-Lymphocyte Escape in the Immunodominant HLA-B27-Restricted Epitope in Human Immunodeficiency Virus Type 1 Capsid. J. Virol. 82: 5594-5605 [Abstract] [Full Text]  
• Seki, S., Kawada, M., Takeda, A., Igarashi, H., Sata, T., Matano, T. (2008). Transmission of Simian Immunodeficiency Virus Carrying Multiple Cytotoxic T-Lymphocyte Escape Mutations with Diminished Replicative Ability Can Result in AIDS Progression in Rhesus Macaques. J. Virol. 82: 5093-5098 [Abstract] [Full Text]  
• Calarota, S. A., Foli, A., Maserati, R., Baldanti, F., Paolucci, S., Young, M. A., Tsoukas, C. M., Lisziewicz, J., Lori, F. (2008). HIV-1-Specific T Cell Precursors with High Proliferative Capacity Correlate with Low Viremia and High CD4 Counts in Untreated Individuals. J. Immunol. 180: 5907-5915 [Abstract] [Full Text]  
• Daucher, M., Price, D. A., Brenchley, J. M., Lamoreaux, L., Metcalf, J. A., Rehm, C., Nies-Kraske, E., Urban, E., Yoder, C., Rock, D., Gumkowski, J., Betts, M. R., Dybul, M. R., Douek, D. C. (2008). Virological Outcome after Structured Interruption of Antiretroviral Therapy for Human Immunodeficiency Virus Infection Is Associated with the Functional Profile of Virus-Specific CD8+ T Cells. J. Virol. 82: 4102-4114 [Abstract] [Full Text]  
• Tagmyer, T. L., Craigo, J. K., Cook, S. J., Even, D. L., Issel, C. J., Montelaro, R. C. (2008). Envelope Determinants of Equine Infectious Anemia Virus Vaccine Protection and the Effects of Sequence Variation on Immune Recognition. J. Virol. 82: 4052-4063 [Abstract] [Full Text]  
• Rehr, M., Cahenzli, J., Haas, A., Price, D. A., Gostick, E., Huber, M., Karrer, U., Oxenius, A. (2008). Emergence of Polyfunctional CD8+ T Cells after Prolonged Suppression of Human Immunodeficiency Virus Replication by Antiretroviral Therapy. J. Virol. 82: 3391-3404 [Abstract] [Full Text]  
• Van Gulck, E. R., Vanham, G., Heyndrickx, L., Coppens, S., Vereecken, K., Atkinson, D., Florence, E., Kint, I., Berneman, Z. N., Tendeloo, V. V. (2008). Efficient In Vitro Expansion of Human Immunodeficiency Virus (HIV)-Specific T-Cell Responses by gag mRNA-Electroporated Dendritic Cells from Treated and Untreated HIV Type 1-Infected Individuals. J. Virol. 82: 3561-3573 [Abstract] [Full Text]  
• Perez, C. L., Larsen, M. V., Gustafsson, R., Norstrom, M. M., Atlas, A., Nixon, D. F., Nielsen, M., Lund, O., Karlsson, A. C. (2008). Broadly Immunogenic HLA Class I Supertype-Restricted Elite CTL Epitopes Recognized in a Diverse Population Infected with Different HIV-1 Subtypes. J. Immunol. 180: 5092-5100 [Abstract] [Full Text]  
• Turk, G., Gherardi, M. M., Laufer, N., Saracco, M., Luzzi, R., Cox, J. H., Cahn, P., Salomon, H. (2008). Magnitude, Breadth, and Functional Profile of T-Cell Responses during Human Immunodeficiency Virus Primary Infection with B and BF Viral Variants. J. Virol. 82: 2853-2866 [Abstract] [Full Text]  
• Balamurugan, A., Lewis, M. J., Kitchen, C. M. R., Robertson, M. N., Shiver, J. W., Daar, E. S., Pitt, J., Ali, A., Ng, H. L., Currier, J. S., Yang, O. O. (2008). Primary Human Immunodeficiency Virus Type 1 (HIV-1) Infection during HIV-1 Gag Vaccination. J. Virol. 82: 2784-2791 [Abstract] [Full Text]  
• Loffredo, J. T., Bean, A. T., Beal, D. R., Leon, E. J., May, G. E., Piaskowski, S. M., Furlott, J. R., Reed, J., Musani, S. K., Rakasz, E. G., Friedrich, T. C., Wilson, N. A., Allison, D. B., Watkins, D. I. (2008). Patterns of CD8+ Immunodominance May Influence the Ability of Mamu-B*08-Positive Macaques To Naturally Control Simian Immunodeficiency Virus SIVmac239 Replication. J. Virol. 82: 1723-1738 [Abstract] [Full Text]  
• Connolly, N. C., Whiteside, T. L., Wilson, C., Kondragunta, V., Rinaldo, C. R., Riddler, S. A. (2008). Therapeutic Immunization with Human Immunodeficiency Virus Type 1 (HIV-1) Peptide-Loaded Dendritic Cells Is Safe and Induces Immunogenicity in HIV-1-Infected Individuals. CVI 15: 284-292 [Abstract] [Full Text]  
• Ueno, T., Motozono, C., Dohki, S., Mwimanzi, P., Rauch, S., Fackler, O. T., Oka, S., Takiguchi, M. (2008). CTL-Mediated Selective Pressure Influences Dynamic Evolution and Pathogenic Functions of HIV-1 Nef. J. Immunol. 180: 1107-1116 [Abstract] [Full Text]  
• Fujiwara, M., Tanuma, J., Koizumi, H., Kawashima, Y., Honda, K., Mastuoka-Aizawa, S., Dohki, S., Oka, S., Takiguchi, M. (2008). Different Abilities of Escape Mutant-Specific Cytotoxic T Cells To Suppress Replication of Escape Mutant and Wild-Type Human Immunodeficiency Virus Type 1 in New Hosts. J. Virol. 82: 138-147 [Abstract] [Full Text]  
• Mueller, Y. M., Do, D. H., Altork, S. R., Artlett, C. M., Gracely, E. J., Katsetos, C. D., Legido, A., Villinger, F., Altman, J. D., Brown, C. R., Lewis, M. G., Katsikis, P. D. (2008). IL-15 Treatment during Acute Simian Immunodeficiency Virus (SIV) Infection Increases Viral Set Point and Accelerates Disease Progression despite the Induction of Stronger SIV-Specific CD8+ T Cell Responses. J. Immunol. 180: 350-360 [Abstract] [Full Text]  
• Geldmacher, C., Gray, C., Nason, M., Currier, J. R., Haule, A., Njovu, L., Geis, S., Hoffmann, O., Maboko, L., Meyerhans, A., Cox, J., Hoelscher, M. (2007). A High Viral Burden Predicts the Loss of CD8 T-Cell Responses Specific for Subdominant Gag Epitopes during Chronic Human Immunodeficiency Virus Infection. J. Virol. 81: 13809-13815 [Abstract] [Full Text]  
• Karlsson, I., Malleret, B., Brochard, P., Delache, B., Calvo, J., Le Grand, R., Vaslin, B. (2007). Dynamics of T-Cell Responses and Memory T Cells during Primary Simian Immunodeficiency Virus Infection in Cynomolgus Macaques. J. Virol. 81: 13456-13468 [Abstract] [Full Text]  
• Wang, C., Wen, T., Routy, J.-P., Bernard, N. F., Sekaly, R. P., Watts, T. H. (2007). 4-1BBL Induces TNF Receptor-Associated Factor 1-Dependent Bim Modulation in Human T Cells and Is a Critical Component in the Costimulation-Dependent Rescue of Functionally Impaired HIV-Specific CD8 T Cells. J. Immunol. 179: 8252-8263 [Abstract] [Full Text]  
• Thobakgale, C. F., Ramduth, D., Reddy, S., Mkhwanazi, N., de Pierres, C., Moodley, E., Mphatswe, W., Blanckenberg, N., Cengimbo, A., Prendergast, A., Tudor-Williams, G., Dong, K., Jeena, P., Kindra, G., Bobat, R., Coovadia, H., Kiepiela, P., Walker, B. D., Goulder, P. J. R. (2007). Human Immunodeficiency Virus-Specific CD8+ T-Cell Activity Is Detectable from Birth in the Majority of In Utero-Infected Infants. J. Virol. 81: 12775-12784 [Abstract] [Full Text]  
• Peut, V., Kent, S. J. (2007). Utility of Human Immunodeficiency Virus Type 1 Envelope as a T-Cell Immunogen. J. Virol. 81: 13125-13134 [Abstract] [Full Text]  
• Liu, Y., McNevin, J., Zhao, H., Tebit, D. M., Troyer, R. M., McSweyn, M., Ghosh, A. K., Shriner, D., Arts, E. J., McElrath, M. J., Mullins, J. I. (2007). Evolution of Human Immunodeficiency Virus Type 1 Cytotoxic T-Lymphocyte Epitopes: Fitness-Balanced Escape. J. Virol. 81: 12179-12188 [Abstract] [Full Text]  
• Tsukamoto, T., Yuasa, M., Yamamoto, H., Kawada, M., Takeda, A., Igarashi, H., Matano, T. (2007). Induction of CD8+ Cells Able To Suppress CCR5-Tropic Simian Immunodeficiency Virus SIVmac239 Replication by Controlled Infection of CXCR4-Tropic Simian-Human Immunodeficiency Virus in Vaccinated Rhesus Macaques. J. Virol. 81: 11640-11649 [Abstract] [Full Text]  
• Hartigan-O'Connor, D. J., Abel, K., McCune, J. M. (2007). Suppression of SIV-specific CD4+ T cells by infant but not adult macaque regulatory T cells: implications for SIV disease progression. J. Exp. Med. 204: 2679-2692 [Abstract] [Full Text]  
• Maness, N. J., Valentine, L. E., May, G. E., Reed, J., Piaskowski, S. M., Soma, T., Furlott, J., Rakasz, E. G., Friedrich, T. C., Price, D. A., Gostick, E., Hughes, A. L., Sidney, J., Sette, A., Wilson, N. A., Watkins, D. I. (2007). AIDS virus specific CD8+ T lymphocytes against an immunodominant cryptic epitope select for viral escape. J. Exp. Med. 204: 2505-2512 [Abstract] [Full Text]  
• Genesca, M., Rourke, T., Li, J., Bost, K., Chohan, B., McChesney, M. B., Miller, C. J. (2007). Live Attenuated Lentivirus Infection Elicits Polyfunctional Simian Immunodeficiency Virus Gag-Specific CD8+ T Cells with Reduced Apoptotic Susceptibility in Rhesus Macaques that Control Virus Replication after Challenge with Pathogenic SIVmac239. J. Immunol. 179: 4732-4740 [Abstract] [Full Text]  
• Navis, M., Schellens, I., van Baarle, D., Borghans, J., van Swieten, P., Miedema, F., Kootstra, N., Schuitemaker, H. (2007). Viral Replication Capacity as a Correlate of HLA B57/B5801-Associated Nonprogressive HIV-1 Infection. J. Immunol. 179: 3133-3143 [Abstract] [Full Text]  
• Brainard, D. M., Tager, A. M., Misdraji, J., Frahm, N., Lichterfeld, M., Draenert, R., Brander, C., Walker, B. D., Luster, A. D. (2007). Decreased CXCR3+ CD8 T Cells in Advanced Human Immunodeficiency Virus Infection Suggest that a Homing Defect Contributes to Cytotoxic T-Lymphocyte Dysfunction. J. Virol. 81: 8439-8450 [Abstract] [Full Text]  
• Petrovas, C., Price, D. A., Mattapallil, J., Ambrozak, D. R., Geldmacher, C., Cecchinato, V., Vaccari, M., Tryniszewska, E., Gostick, E., Roederer, M., Douek, D. C., Morgan, S. H., Davis, S. J., Franchini, G., Koup, R. A. (2007). SIV-specific CD8+ T cells express high levels of PD1 and cytokines but have impaired proliferative capacity in acute and chronic SIVmac251 infection. Blood 110: 928-936 [Abstract] [Full Text]  
• Streeck, H., Lichterfeld, M., Alter, G., Meier, A., Teigen, N., Yassine-Diab, B., Sidhu, H. K., Little, S., Kelleher, A., Routy, J.-P., Rosenberg, E. S., Sekaly, R.-P., Walker, B. D., Altfeld, M. (2007). Recognition of a Defined Region within p24 Gag by CD8+ T Cells during Primary Human Immunodeficiency Virus Type 1 Infection in Individuals Expressing Protective HLA Class I Alleles. J. Virol. 81: 7725-7731 [Abstract] [Full Text]  
• Yang, H., Dong, T., Turnbull, E., Ranasinghe, S., Ondondo, B., Goonetilleke, N., Winstone, N., di Gleria, K., Bowness, P., Conlon, C., Borrow, P., Hanke, T., McMichael, A., Dorrell, L. (2007). Broad TCR Usage in Functional HIV-1-Specific CD8+ T Cell Expansions Driven by Vaccination during Highly Active Antiretroviral Therapy. J. Immunol. 179: 597-606 [Abstract] [Full Text]  
• Precopio, M. L., Betts, M. R., Parrino, J., Price, D. A., Gostick, E., Ambrozak, D. R., Asher, T. E., Douek, D. C., Harari, A., Pantaleo, G., Bailer, R., Graham, B. S., Roederer, M., Koup, R. A. (2007). Immunization with vaccinia virus induces polyfunctional and phenotypically distinctive CD8+ T cell responses. J. Exp. Med. 204: 1405-1416 [Abstract] [Full Text]  
• Connick, E., Mattila, T., Folkvord, J. M., Schlichtemeier, R., Meditz, A. L., Ray, M. G., McCarter, M. D., MaWhinney, S., Hage, A., White, C., Skinner, P. J. (2007). CTL Fail to Accumulate at Sites of HIV-1 Replication in Lymphoid Tissue. J. Immunol. 178: 6975-6983 [Abstract] [Full Text]  
• Kawada, M., Tsukamoto, T., Yamamoto, H., Takeda, A., Igarashi, H., Watkins, D. I., Matano, T. (2007). Long-Term Control of Simian Immunodeficiency Virus Replication with Central Memory CD4+ T-Cell Preservation after Nonsterile Protection by a Cytotoxic T-Lymphocyte-Based Vaccine. J. Virol. 81: 5202-5211 [Abstract] [Full Text]  
• Lichterfeld, M., Yu, X. G., Mui, S. K., Williams, K. L., Trocha, A., Brockman, M. A., Allgaier, R. L., Waring, M. T., Koibuchi, T., Johnston, M. N., Cohen, D., Allen, T. M., Rosenberg, E. S., Walker, B. D., Altfeld, M. (2007). Selective Depletion of High-Avidity Human Immunodeficiency Virus Type 1 (HIV-1)-Specific CD8+ T Cells after Early HIV-1 Infection. J. Virol. 81: 4199-4214 [Abstract] [Full Text]  
• Geldmacher, C., Currier, J. R., Herrmann, E., Haule, A., Kuta, E., McCutchan, F., Njovu, L., Geis, S., Hoffmann, O., Maboko, L., Williamson, C., Birx, D., Meyerhans, A., Cox, J., Hoelscher, M. (2007). CD8 T-Cell Recognition of Multiple Epitopes within Specific Gag Regions Is Associated with Maintenance of a Low Steady-State Viremia in Human Immunodeficiency Virus Type 1-Seropositive Patients. J. Virol. 81: 2440-2448 [Abstract] [Full Text]  
• Kinter, A., McNally, J., Riggin, L., Jackson, R., Roby, G., Fauci, A. S. (2007). Suppression of HIV-specific T cell activity by lymph node CD25+ regulatory T cells from HIV-infected individuals. Proc. Natl. Acad. Sci. USA 104: 3390-3395 [Abstract] [Full Text]  
• Yamamoto, H., Kawada, M., Tsukamoto, T., Takeda, A., Igarashi, H., Miyazawa, M., Naruse, T., Yasunami, M., Kimura, A., Matano, T. (2007). Vaccine-based, long-term, stable control of simian/human immunodeficiency virus 89.6PD replication in rhesus macaques. J. Gen. Virol. 88: 652-659 [Abstract] [Full Text]  
• Chung, C., Lee, W., Loffredo, J. T., Burwitz, B., Friedrich, T. C., Giraldo Vela, J. P., Napoe, G., Rakasz, E. G., Wilson, N. A., Allison, D. B., Watkins, D. I. (2007). Not All Cytokine-Producing CD8+ T Cells Suppress Simian Immunodeficiency Virus Replication. J. Virol. 81: 1517-1523 [Abstract] [Full Text]  
• Day, C. L., Kiepiela, P., Leslie, A. J., van der Stok, M., Nair, K., Ismail, N., Honeyborne, I., Crawford, H., Coovadia, H. M., Goulder, P. J. R., Walker, B. D., Klenerman, P. (2007). Proliferative Capacity of Epitope-Specific CD8 T-Cell Responses Is Inversely Related to Viral Load in Chronic Human Immunodeficiency Virus Type 1 Infection. J. Virol. 81: 434-438 [Abstract] [Full Text]  
• Li, B., Gladden, A. D., Altfeld, M., Kaldor, J. M., Cooper, D. A., Kelleher, A. D., Allen, T. M. (2007). Rapid Reversion of Sequence Polymorphisms Dominates Early Human Immunodeficiency Virus Type 1 Evolution. J. Virol. 81: 193-201 [Abstract] [Full Text]  
• Mealey, R. H., Lee, J.-H., Leib, S. R., Littke, M. H., McGuire, T. C. (2006). A Single Amino Acid Difference within the {alpha}-2 Domain of Two Naturally Occurring Equine MHC Class I Molecules Alters the Recognition of Gag and Rev Epitopes by Equine Infectious Anemia Virus-Specific CTL. J. Immunol. 177: 7377-7390 [Abstract] [Full Text]  
• Adnan, S., Balamurugan, A., Trocha, A., Bennett, M. S., Ng, H. L., Ali, A., Brander, C., Yang, O. O. (2006). Nef interference with HIV-1-specific CTL antiviral activity is epitope specific. Blood 108: 3414-3419 [Abstract] [Full Text]  
• VandeWoude, S., Apetrei, C. (2006). Going Wild: Lessons from Naturally Occurring T-Lymphotropic Lentiviruses. Clin. Microbiol. Rev. 19: 728-762 [Abstract] [Full Text]  
• Liu, Y., McNevin, J., Cao, J., Zhao, H., Genowati, I., Wong, K., McLaughlin, S., McSweyn, M. D., Diem, K., Stevens, C. E., Maenza, J., He, H., Nickle, D. C., Shriner, D., Holte, S. E., Collier, A. C., Corey, L., McElrath, M. J., Mullins, J. I. (2006). Selection on the Human Immunodeficiency Virus Type 1 Proteome following Primary Infection. J. Virol. 80: 9519-9529 [Abstract] [Full Text]  
• Dunham, R., Pagliardini, P., Gordon, S., Sumpter, B., Engram, J., Moanna, A., Paiardini, M., Mandl, J. N., Lawson, B., Garg, S., McClure, H. M., Xu, Y.-X., Ibegbu, C., Easley, K., Katz, N., Pandrea, I., Apetrei, C., Sodora, D. L., Staprans, S. I., Feinberg, M. B., Silvestri, G. (2006). The AIDS resistance of naturally SIV-infected sooty mangabeys is independent of cellular immunity to the virus. Blood 108: 209-217 [Abstract] [Full Text]  
• Betts, M. R., Nason, M. C., West, S. M., De Rosa, S. C., Migueles, S. A., Abraham, J., Lederman, M. M., Benito, J. M., Goepfert, P. A., Connors, M., Roederer, M., Koup, R. A. (2006). HIV nonprogressors preferentially maintain highly functional HIV-specific CD8+ T cells. Blood 107: 4781-4789 [Abstract] [Full Text]  
• Kubo, M., Nishitsuji, H., Kurihara, K., Hayashi, T., Masuda, T., Kannagi, M. (2006). Suppression of human immunodeficiency virus type 1 replication by arginine deiminase of Mycoplasma arginini. J. Gen. Virol. 87: 1589-1593 [Abstract] [Full Text]  
• Kan-Mitchell, J., Bajcz, M., Schaubert, K. L., Price, D. A., Brenchley, J. M., Asher, T. E., Douek, D. C., Ng, H. L., Yang, O. O., Rinaldo, C. R. Jr., Benito, J. M., Bisikirska, B., Hegde, R., Marincola, F. M., Boggiano, C., Wilson, D., Abrams, J., Blondelle, S. E., Wilson, D. B. (2006). Degeneracy and Repertoire of the Human HIV-1 Gag p1777-85 CTL Response.. J. Immunol. 176: 6690-6701 [Abstract] [Full Text]  
• Bailey, J. R., Williams, T. M., Siliciano, R. F., Blankson, J. N. (2006). Maintenance of viral suppression in HIV-1-infected HLA-B*57+ elite suppressors despite CTL escape mutations. J. Exp. Med. 203: 1357-1369 [Abstract] [Full Text]  
• Goonetilleke, N., Moore, S., Dally, L., Winstone, N., Cebere, I., Mahmoud, A., Pinheiro, S., Gillespie, G., Brown, D., Loach, V., Roberts, J., Guimaraes-Walker, A., Hayes, P., Loughran, K., Smith, C., De Bont, J., Verlinde, C., Vooijs, D., Schmidt, C., Boaz, M., Gilmour, J., Fast, P., Dorrell, L., Hanke, T., McMichael, A. J. (2006). Induction of Multifunctional Human Immunodeficiency Virus Type 1 (HIV-1)-Specific T Cells Capable of Proliferation in Healthy Subjects by Using a Prime-Boost Regimen of DNA- and Modified Vaccinia Virus Ankara-Vectored Vaccines Expressing HIV-1 Gag Coupled to CD8+ T-Cell Epitopes.. J. Virol. 80: 4717-4728 [Abstract] [Full Text]  
• Acierno, P. M., Schmitz, J. E., Gorgone, D. A., Sun, Y., Santra, S., Seaman, M. S., Newberg, M. H., Mascola, J. R., Nabel, G. J., Panicali, D., Letvin, N. L. (2006). Preservation of Functional Virus-Specific Memory CD8+ T Lymphocytes in Vaccinated, Simian Human Immunodeficiency Virus-Infected Rhesus Monkeys. J. Immunol. 176: 5338-5345 [Abstract] [Full Text]  
• Wang, Z., Metcalf, B., Ribeiro, R. M., McClure, H., Kaur, A. (2006). Th-1-Type Cytotoxic CD8+ T-Lymphocyte Responses to Simian Immunodeficiency Virus (SIV) Are a Consistent Feature of Natural SIV Infection in Sooty Mangabeys. J. Virol. 80: 2771-2783 [Abstract] [Full Text]  
• Meyer-Olson, D., Brady, K. W., Bartman, M. T., O'Sullivan, K. M., Simons, B. C., Conrad, J. A., Duncan, C. B., Lorey, S., Siddique, A., Draenert, R., Addo, M., Altfeld, M., Rosenberg, E., Allen, T. M., Walker, B. D., Kalams, S. A. (2006). Fluctuations of functionally distinct CD8+ T-cell clonotypes demonstrate flexibility of the HIV-specific TCR repertoire. Blood 107: 2373-2383 [Abstract] [Full Text]  
• Kawada, M., Igarashi, H., Takeda, A., Tsukamoto, T., Yamamoto, H., Dohki, S., Takiguchi, M., Matano, T. (2006). Involvement of Multiple Epitope-Specific Cytotoxic T-Lymphocyte Responses in Vaccine-Based Control of Simian Immunodeficiency Virus Replication in Rhesus Macaques. J. Virol. 80: 1949-1958 [Abstract] [Full Text]  
• Elrefaei, M., Barugahare, B., Ssali, F., Mugyenyi, P., Cao, H. (2006). HIV-Specific IL-10-Positive CD8+ T Cells Are Increased in Advanced Disease and Are Associated with Decreased HIV-Specific Cytolysis. J. Immunol. 176: 1274-1280 [Abstract] [Full Text]  
• Yang, O. O., Church, J., Kitchen, C. M. R., Kilpatrick, R., Ali, A., Geng, Y., Killian, M. S., Sabado, R. L., Ng, H., Suen, J., Bryson, Y., Jamieson, B. D., Krogstad, P. (2005). Genetic and Stochastic Influences on the Interaction of Human Immunodeficiency Virus Type 1 and Cytotoxic T Lymphocytes in Identical Twins. J. Virol. 79: 15368-15375 [Abstract] [Full Text]  
• Mao, H., Lafont, B. A. P., Igarashi, T., Nishimura, Y., Brown, C., Hirsch, V., Buckler-White, A., Sadjadpour, R., Martin, M. A. (2005). CD8+ and CD20+ Lymphocytes Cooperate To Control Acute Simian Immunodeficiency Virus/Human Immunodeficiency Virus Chimeric Virus Infections in Rhesus Monkeys: Modulation by Major Histocompatibility Complex Genotype. J. Virol. 79: 14887-14898 [Abstract] [Full Text]  
• Loffredo, J. T., Rakasz, E. G., Giraldo, J. P., Spencer, S. P., Grafton, K. K., Martin, S. R., Napoe, G., Yant, L. J., Wilson, N. A., Watkins, D. I. (2005). Tat28-35SL8-Specific CD8+ T Lymphocytes Are More Effective than Gag181-189CM9-Specific CD8+ T Lymphocytes at Suppressing Simian Immunodeficiency Virus Replication in a Functional In Vitro Assay. J. Virol. 79: 14986-14991 [Abstract] [Full Text]  
• Milicic, A., Edwards, C. T. T., Hue, S., Fox, J., Brown, H., Pillay, T., Drijfhout, J. W., Weber, J. N., Holmes, E. C., Fidler, S. J., Zhang, H.-T., Phillips, R. E. (2005). Sexual Transmission of Single Human Immunodeficiency Virus Type 1 Virions Encoding Highly Polymorphic Multisite Cytotoxic T-Lymphocyte Escape Variants. J. Virol. 79: 13953-13962 [Abstract] [Full Text]  
• Sanchez-Merino, V., Nie, S., Luzuriaga, K. (2005). HIV-1-Specific CD8+ T Cell Responses and Viral Evolution in Women and Infants. J. Immunol. 175: 6976-6986 [Abstract] [Full Text]  
• Loffredo, J. T., Sidney, J., Piaskowski, S., Szymanski, A., Furlott, J., Rudersdorf, R., Reed, J., Peters, B., Hickman-Miller, H. D., Bardet, W., Rehrauer, W. M., O'Connor, D. H., Wilson, N. A., Hildebrand, W. H., Sette, A., Watkins, D. I. (2005). The High Frequency Indian Rhesus Macaque MHC Class I Molecule, Mamu-B*01, Does Not Appear to Be Involved in CD8+ T Lymphocyte Responses to SIVmac239. J. Immunol. 175: 5986-5997 [Abstract] [Full Text]  
• Bernardin, F., Kong, D., Peddada, L., Baxter-Lowe, L. A., Delwart, E. (2005). Human Immunodeficiency Virus Mutations during the First Month of Infection Are Preferentially Found in Known Cytotoxic T-Lymphocyte Epitopes. J. Virol. 79: 11523-11528 [Abstract] [Full Text]  
• Kobayashi, M., Igarashi, H., Takeda, A., Kato, M., Matano, T. (2005). Reversion In Vivo after Inoculation of a Molecular Proviral DNA Clone of Simian Immunodeficiency Virus with a Cytotoxic-T-Lymphocyte Escape Mutation. J. Virol. 79: 11529-11532 [Abstract] [Full Text]  
• Stewart-Jones, G. B. E., Gillespie, G., Overton, I. M., Kaul, R., Roche, P., McMichael, A. J., Rowland-Jones, S., Jones, E. Y. (2005). Structures of Three HIV-1 HLA-B*5703-Peptide Complexes and Identification of Related HLAs Potentially Associated with Long-Term Nonprogression. J. Immunol. 175: 2459-2468 [Abstract] [Full Text]  
• Reynolds, M. R., Rakasz, E., Skinner, P. J., White, C., Abel, K., Ma, Z.-M., Compton, L., Napoe, G., Wilson, N., Miller, C. J., Haase, A., Watkins, D. I. (2005). CD8+ T-Lymphocyte Response to Major Immunodominant Epitopes after Vaginal Exposure to Simian Immunodeficiency Virus: Too Late and Too Little. J. Virol. 79: 9228-9235 [Abstract] [Full Text]  
• Edwards, C. T. T., Pfafferott, K. J., Goulder, P. J. R., Phillips, R. E., Holmes, E. C. (2005). Intrapatient Escape in the A*0201-Restricted Epitope SLYNTVATL Drives Evolution of Human Immunodeficiency Virus Type 1 at the Population Level. J. Virol. 79: 9363-9366 [Abstract] [Full Text]  
• Koibuchi, T., Allen, T. M., Lichterfeld, M., Mui, S. K., O'Sullivan, K. M., Trocha, A., Kalams, S. A., Johnson, R. P., Walker, B. D. (2005). Limited Sequence Evolution within Persistently Targeted CD8 Epitopes in Chronic Human Immunodeficiency Virus Type 1 Infection. J. Virol. 79: 8171-8181 [Abstract] [Full Text]  
• Otten, G. R., Schaefer, M., Doe, B., Liu, H., Srivastava, I., zur Megede, J., Kazzaz, J., Lian, Y., Singh, M., Ugozzoli, M., Montefiori, D., Lewis, M., Driver, D. A., Dubensky, T., Polo, J. M., Donnelly, J., O'Hagan, D. T., Barnett, S., Ulmer, J. B. (2005). Enhanced Potency of Plasmid DNA Microparticle Human Immunodeficiency Virus Vaccines in Rhesus Macaques by Using a Priming-Boosting Regimen with Recombinant Proteins. J. Virol. 79: 8189-8200 [Abstract] [Full Text]  
• Mueller, Y. M., Petrovas, C., Bojczuk, P. M., Dimitriou, I. D., Beer, B., Silvera, P., Villinger, F., Cairns, J. S., Gracely, E. J., Lewis, M. G., Katsikis, P. D. (2005). Interleukin-15 Increases Effector Memory CD8+ T Cells and NK Cells in Simian Immunodeficiency Virus-Infected Macaques. J. Virol. 79: 4877-4885 [Abstract] [Full Text]  
• Peretz, Y., Alter, G., Boisvert, M.-P., Hatzakis, G., Tsoukas, C. M., Bernard, N. F. (2005). Human Immunodeficiency Virus (HIV)-Specific Gamma Interferon Secretion Directed against All Expressed HIV Genes: Relationship to Rate of CD4 Decline. J. Virol. 79: 4908-4917 [Abstract] [Full Text]  
• Silvestri, G., Fedanov, A., Germon, S., Kozyr, N., Kaiser, W. J., Garber, D. A., McClure, H., Feinberg, M. B., Staprans, S. I. (2005). Divergent Host Responses during Primary Simian Immunodeficiency Virus SIVsm Infection of Natural Sooty Mangabey and Nonnatural Rhesus Macaque Hosts. J. Virol. 79: 4043-4054 [Abstract] [Full Text]  
• Ibarrondo, F. J., Anton, P. A., Fuerst, M., Ng, H. L., Wong, J. T., Matud, J., Elliott, J., Shih, R., Hausner, M. A., Price, C., Hultin, L. E., Hultin, P. M., Jamieson, B. D., Yang, O. O. (2005). Parallel Human Immunodeficiency Virus Type 1-Specific CD8+ T-Lymphocyte Responses in Blood and Mucosa during Chronic Infection. J. Virol. 79: 4289-4297 [Abstract] [Full Text]  
• Casazza, J. P., Betts, M. R., Hill, B. J., Brenchley, J. M., Price, D. A., Douek, D. C., Koup, R. A. (2005). Immunologic Pressure within Class I-Restricted Cognate Human Immunodeficiency Virus Epitopes during Highly Active Antiretroviral Therapy. J. Virol. 79: 3653-3663 [Abstract] [Full Text]  
• Chea, S., Dale, C. J., De Rose, R., Ramshaw, I. A., Kent, S. J. (2005). Enhanced Cellular Immunity in Macaques following a Novel Peptide Immunotherapy. J. Virol. 79: 3748-3757 [Abstract] [Full Text]  
• Aasa-Chapman, M. M. I., Holuigue, S., Aubin, K., Wong, M., Jones, N. A., Cornforth, D., Pellegrino, P., Newton, P., Williams, I., Borrow, P., McKnight, A. (2005). Detection of Antibody-Dependent Complement-Mediated Inactivation of both Autologous and Heterologous Virus in Primary Human Immunodeficiency Virus Type 1 Infection. J. Virol. 79: 2823-2830 [Abstract] [Full Text]  
• Nacsa, J., Edghill-Smith, Y., Tsai, W.-P., Venzon, D., Tryniszewska, E., Hryniewicz, A., Moniuszko, M., Kinter, A., Smith, K. A., Franchini, G. (2005). Contrasting Effects of Low-Dose IL-2 on Vaccine-Boosted Simian Immunodeficiency Virus (SIV)-Specific CD4+ and CD8+ T Cells in Macaques Chronically Infected with SIVmac251. J. Immunol. 174: 1913-1921 [Abstract] [Full Text]  
• Zheng, N. N., Kiviat, N. B., Sow, P. S., Hawes, S. E., Wilson, A., Diallo-Agne, H., Critchlow, C. W., Gottlieb, G. S., Musey, L., McElrath, M. J. (2004). Comparison of Human Immunodeficiency Virus (HIV)-Specific T-Cell Responses in HIV-1- and HIV-2-Infected Individuals in Senegal. J. Virol. 78: 13934-13942 [Abstract] [Full Text]  
• Aandahl, E. M., Quigley, M. F., Moretto, W. J., Moll, M., Gonzalez, V. D., Sonnerborg, A., Lindback, S., Hecht, F. M., Deeks, S. G., Rosenberg, M. G., Nixon, D. F., Sandberg, J. K. (2004). Expansion of CD7low and CD7negative CD8 T-cell effector subsets in HIV-1 infection: correlation with antigenic load and reversion by antiretroviral treatment. Blood 104: 3672-3678 [Abstract] [Full Text]  
• Jones, N. A., Wei, X., Flower, D. R., Wong, M., Michor, F., Saag, M. S., Hahn, B. H., Nowak, M. A., Shaw, G. M., Borrow, P. (2004). Determinants of Human Immunodeficiency Virus Type 1 Escape from the Primary CD8+ Cytotoxic T Lymphocyte Response. J. Exp. Med. 200: 1243-1256 [Abstract] [Full Text]  
• Dagarag, M., Evazyan, T., Rao, N., Effros, R. B. (2004). Genetic Manipulation of Telomerase in HIV-Specific CD8+ T Cells: Enhanced Antiviral Functions Accompany the Increased Proliferative Potential and Telomere Length Stabilization. J. Immunol. 173: 6303-6311 [Abstract] [Full Text]  
• Davenport, M. P., Ribeiro, R. M., Chao, D. L., Perelson, A. S. (2004). Predicting the Impact of a Nonsterilizing Vaccine against Human Immunodeficiency Virus. J. Virol. 78: 11340-11351 [Abstract] [Full Text]  
• Loffredo, J. T., Sidney, J., Wojewoda, C., Dodds, E., Reynolds, M. R., Napoe, G., Mothe, B. R., O'Connor, D. H., Wilson, N. A., Watkins, D. I., Sette, A. (2004). Identification of Seventeen New Simian Immunodeficiency Virus-Derived CD8+ T Cell Epitopes Restricted by the High Frequency Molecule, Mamu-A*02, and Potential Escape from CTL Recognition. J. Immunol. 173: 5064-5076 [Abstract] [Full Text]  
• Zhang, H., Fayad, R., Wang, X., Quinn, D., Qiao, L. (2004). Human Immunodeficiency Virus Type 1 Gag-Specific Mucosal Immunity after Oral Immunization with Papillomavirus Pseudoviruses Encoding Gag. J. Virol. 78: 10249-10257 [Abstract] [Full Text]  
• Masemola, A. M., Mashishi, T. N., Khoury, G., Bredell, H., Paximadis, M., Mathebula, T., Barkhan, D., Puren, A., Vardas, E., Colvin, M., Zijenah, L., Katzenstein, D., Musonda, R., Allen, S., Kumwenda, N., Taha, T., Gray, G., McIntyre, J., Karim, S. A., Sheppard, H. W., Gray, C. M. (2004). Novel and Promiscuous CTL Epitopes in Conserved Regions of Gag Targeted by Individuals with Early Subtype C HIV Type 1 Infection from Southern Africa. J. Immunol. 173: 4607-4617 [Abstract] [Full Text]  
• Bonaparte, M. I., Barker, E. (2004). Killing of human immunodeficiency virus-infected primary T-cell blasts by autologous natural killer cells is dependent on the ability of the virus to alter the expression of major histocompatibility complex class I molecules. Blood 104: 2087-2094 [Abstract] [Full Text]  
• Lichterfeld, M., Kaufmann, D. E., Yu, X. G., Mui, S. K., Addo, M. M., Johnston, M. N., Cohen, D., Robbins, G. K., Pae, E., Alter, G., Wurcel, A., Stone, D., Rosenberg, E. S., Walker, B. D., Altfeld, M. (2004). Loss of HIV-1-specific CD8+ T Cell Proliferation after Acute HIV-1 Infection and Restoration by Vaccine-induced HIV-1-specific CD4+ T Cells. J. Exp. Med. 200: 701-712 [Abstract] [Full Text]  
• Friedrich, T. C., McDermott, A. B., Reynolds, M. R., Piaskowski, S., Fuenger, S., de Souza, I. P., Rudersdorf, R., Cullen, C., Yant, L. J., Vojnov, L., Stephany, J., Martin, S., O'Connor, D. H., Wilson, N., Watkins, D. I. (2004). Consequences of Cytotoxic T-Lymphocyte Escape: Common Escape Mutations in Simian Immunodeficiency Virus Are Poorly Recognized in Naive Hosts. J. Virol. 78: 10064-10073 [Abstract] [Full Text]  
• Davenport, M. P., Ribeiro, R. M., Perelson, A. S. (2004). Kinetics of Virus-Specific CD8+ T Cells and the Control of Human Immunodeficiency Virus Infection. J. Virol. 78: 10096-10103 [Abstract] [Full Text]