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J Virol. 1994 July; 68(7): 4650-4655

Temporal association of cellular immune responses with the initial control of viremia in primary human immunodeficiency virus type 1 syndrome.

R A Koup, J T Safrit, Y Cao, C A Andrews, G McLeod, W Borkowsky, C Farthing and D D Ho

Aaron Diamond AIDS Research Center, New York University School of Medicine, New York 10016.

ABSTRACT

Virologic and immunologic studies were performed on five patients presenting with primary human immunodeficiency virus type 1 (HIV-1) infection. CD8+ cytotoxic T lymphocyte (CTL) precursors specific for cells expressing antigens of HIV-1 Gag, Pol, and Env were detected at or within 3 weeks of presentation in four of the five patients and were detected in all five patients by 3 to 6 months after presentation. The one patient with an absent initial CTL response had prolonged symptoms, persistent viremia, and low CD4+ T-cell count. Neutralizing antibody activity was absent at the time of presentation in all five patients. These findings suggest that cellular immunity is involved in the initial control of virus replication in primary HIV-1 infection and indicate a role for CTL in protective immunity to HIV-1 in vivo.

J Virol. 1994 July; 68(7): 4650-4655




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  • Tagmyer, T. L., Craigo, J. K., Cook, S. J., Even, D. L., Issel, C. J., Montelaro, R. C. (2008). Envelope Determinants of Equine Infectious Anemia Virus Vaccine Protection and the Effects of Sequence Variation on Immune Recognition. J. Virol. 82: 4052-4063 [Abstract] [Full Text]  
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  • Rehr, M., Cahenzli, J., Haas, A., Price, D. A., Gostick, E., Huber, M., Karrer, U., Oxenius, A. (2008). Emergence of Polyfunctional CD8+ T Cells after Prolonged Suppression of Human Immunodeficiency Virus Replication by Antiretroviral Therapy. J. Virol. 82: 3391-3404 [Abstract] [Full Text]  
  • Van Gulck, E. R., Vanham, G., Heyndrickx, L., Coppens, S., Vereecken, K., Atkinson, D., Florence, E., Kint, I., Berneman, Z. N., Tendeloo, V. V. (2008). Efficient In Vitro Expansion of Human Immunodeficiency Virus (HIV)-Specific T-Cell Responses by gag mRNA-Electroporated Dendritic Cells from Treated and Untreated HIV Type 1-Infected Individuals. J. Virol. 82: 3561-3573 [Abstract] [Full Text]  
  • Perez, C. L., Larsen, M. V., Gustafsson, R., Norstrom, M. M., Atlas, A., Nixon, D. F., Nielsen, M., Lund, O., Karlsson, A. C. (2008). Broadly Immunogenic HLA Class I Supertype-Restricted Elite CTL Epitopes Recognized in a Diverse Population Infected with Different HIV-1 Subtypes. J. Immunol. 180: 5092-5100 [Abstract] [Full Text]  
  • Mooij, P., Balla-Jhagjhoorsingh, S. S., Koopman, G., Beenhakker, N., van Haaften, P., Baak, I., Nieuwenhuis, I. G., Kondova, I., Wagner, R., Wolf, H., Gomez, C. E., Najera, J. L., Jimenez, V., Esteban, M., Heeney, J. L. (2008). Differential CD4+ versus CD8+ T-Cell Responses Elicited by Different Poxvirus-Based Human Immunodeficiency Virus Type 1 Vaccine Candidates Provide Comparable Efficacies in Primates. J. Virol. 82: 2975-2988 [Abstract] [Full Text]  
  • Joseph, A., Zheng, J. H., Follenzi, A., DiLorenzo, T., Sango, K., Hyman, J., Chen, K., Piechocka-Trocha, A., Brander, C., Hooijberg, E., Vignali, D. A., Walker, B. D., Goldstein, H. (2008). Lentiviral Vectors Encoding Human Immunodeficiency Virus Type 1 (HIV-1)-Specific T-Cell Receptor Genes Efficiently Convert Peripheral Blood CD8 T Lymphocytes into Cytotoxic T Lymphocytes with Potent In Vitro and In Vivo HIV-1-Specific Inhibitory Activity. J. Virol. 82: 3078-3089 [Abstract] [Full Text]  
  • Balamurugan, A., Lewis, M. J., Kitchen, C. M. R., Robertson, M. N., Shiver, J. W., Daar, E. S., Pitt, J., Ali, A., Ng, H. L., Currier, J. S., Yang, O. O. (2008). Primary Human Immunodeficiency Virus Type 1 (HIV-1) Infection during HIV-1 Gag Vaccination. J. Virol. 82: 2784-2791 [Abstract] [Full Text]  
  • Loffredo, J. T., Bean, A. T., Beal, D. R., Leon, E. J., May, G. E., Piaskowski, S. M., Furlott, J. R., Reed, J., Musani, S. K., Rakasz, E. G., Friedrich, T. C., Wilson, N. A., Allison, D. B., Watkins, D. I. (2008). Patterns of CD8+ Immunodominance May Influence the Ability of Mamu-B*08-Positive Macaques To Naturally Control Simian Immunodeficiency Virus SIVmac239 Replication. J. Virol. 82: 1723-1738 [Abstract] [Full Text]  
  • Connolly, N. C., Whiteside, T. L., Wilson, C., Kondragunta, V., Rinaldo, C. R., Riddler, S. A. (2008). Therapeutic Immunization with Human Immunodeficiency Virus Type 1 (HIV-1) Peptide-Loaded Dendritic Cells Is Safe and Induces Immunogenicity in HIV-1-Infected Individuals. CVI 15: 284-292 [Abstract] [Full Text]  
  • Ueno, T., Motozono, C., Dohki, S., Mwimanzi, P., Rauch, S., Fackler, O. T., Oka, S., Takiguchi, M. (2008). CTL-Mediated Selective Pressure Influences Dynamic Evolution and Pathogenic Functions of HIV-1 Nef. J. Immunol. 180: 1107-1116 [Abstract] [Full Text]  
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  • Mueller, Y. M., Do, D. H., Altork, S. R., Artlett, C. M., Gracely, E. J., Katsetos, C. D., Legido, A., Villinger, F., Altman, J. D., Brown, C. R., Lewis, M. G., Katsikis, P. D. (2008). IL-15 Treatment during Acute Simian Immunodeficiency Virus (SIV) Infection Increases Viral Set Point and Accelerates Disease Progression despite the Induction of Stronger SIV-Specific CD8+ T Cell Responses. J. Immunol. 180: 350-360 [Abstract] [Full Text]  
  • Geldmacher, C., Gray, C., Nason, M., Currier, J. R., Haule, A., Njovu, L., Geis, S., Hoffmann, O., Maboko, L., Meyerhans, A., Cox, J., Hoelscher, M. (2007). A High Viral Burden Predicts the Loss of CD8 T-Cell Responses Specific for Subdominant Gag Epitopes during Chronic Human Immunodeficiency Virus Infection. J. Virol. 81: 13809-13815 [Abstract] [Full Text]  
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  • Wang, C., Wen, T., Routy, J.-P., Bernard, N. F., Sekaly, R. P., Watts, T. H. (2007). 4-1BBL Induces TNF Receptor-Associated Factor 1-Dependent Bim Modulation in Human T Cells and Is a Critical Component in the Costimulation-Dependent Rescue of Functionally Impaired HIV-Specific CD8 T Cells. J. Immunol. 179: 8252-8263 [Abstract] [Full Text]  
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  • Boyer, J. D., Robinson, T. M., Kutzler, M. A., Vansant, G., Hokey, D. A., Kumar, S., Parkinson, R., Wu, L., Sidhu, M. K., Pavlakis, G. N., Felber, B. K., Brown, C., Silvera, P., Lewis, M. G., Monforte, J., Waldmann, T. A., Eldridge, J., Weiner, D. B. (2007). Protection against simian/human immunodeficiency virus (SHIV) 89.6P in macaques after coimmunization with SHIV antigen and IL-15 plasmid. Proc. Natl. Acad. Sci. USA 104: 18648-18653 [Abstract] [Full Text]  
  • Liu, Y., McNevin, J., Zhao, H., Tebit, D. M., Troyer, R. M., McSweyn, M., Ghosh, A. K., Shriner, D., Arts, E. J., McElrath, M. J., Mullins, J. I. (2007). Evolution of Human Immunodeficiency Virus Type 1 Cytotoxic T-Lymphocyte Epitopes: Fitness-Balanced Escape. J. Virol. 81: 12179-12188 [Abstract] [Full Text]  
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  • Sacha, J. B., Chung, C., Reed, J., Jonas, A. K., Bean, A. T., Spencer, S. P., Lee, W., Vojnov, L., Rudersdorf, R., Friedrich, T. C., Wilson, N. A., Lifson, J. D., Watkins, D. I. (2007). Pol-Specific CD8+ T Cells Recognize Simian Immunodeficiency Virus-Infected Cells Prior to Nef-Mediated Major Histocompatibility Complex Class I Downregulation. J. Virol. 81: 11703-11712 [Abstract] [Full Text]  
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  • Hartigan-O'Connor, D. J., Abel, K., McCune, J. M. (2007). Suppression of SIV-specific CD4+ T cells by infant but not adult macaque regulatory T cells: implications for SIV disease progression. JEM 204: 2679-2692 [Abstract] [Full Text]  
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  • Genesca, M., Rourke, T., Li, J., Bost, K., Chohan, B., McChesney, M. B., Miller, C. J. (2007). Live Attenuated Lentivirus Infection Elicits Polyfunctional Simian Immunodeficiency Virus Gag-Specific CD8+ T Cells with Reduced Apoptotic Susceptibility in Rhesus Macaques that Control Virus Replication after Challenge with Pathogenic SIVmac239. J. Immunol. 179: 4732-4740 [Abstract] [Full Text]  
  • Tatsis, N., Fitzgerald, J. C., Reyes-Sandoval, A., Harris-McCoy, K. C., Hensley, S. E., Zhou, D., Lin, S.-W., Bian, A., Xiang, Z. Q., Iparraguirre, A., Lopez-Camacho, C., Wherry, E. J., Ertl, H. C. J. (2007). Adenoviral vectors persist in vivo and maintain activated CD8+ T cells: implications for their use as vaccines. Blood 110: 1916-1923 [Abstract] [Full Text]  
  • Navis, M., Schellens, I., van Baarle, D., Borghans, J., van Swieten, P., Miedema, F., Kootstra, N., Schuitemaker, H. (2007). Viral Replication Capacity as a Correlate of HLA B57/B5801-Associated Nonprogressive HIV-1 Infection. J. Immunol. 179: 3133-3143 [Abstract] [Full Text]  
  • Brainard, D. M., Tager, A. M., Misdraji, J., Frahm, N., Lichterfeld, M., Draenert, R., Brander, C., Walker, B. D., Luster, A. D. (2007). Decreased CXCR3+ CD8 T Cells in Advanced Human Immunodeficiency Virus Infection Suggest that a Homing Defect Contributes to Cytotoxic T-Lymphocyte Dysfunction. J. Virol. 81: 8439-8450 [Abstract] [Full Text]  
  • Streeck, H., Lichterfeld, M., Alter, G., Meier, A., Teigen, N., Yassine-Diab, B., Sidhu, H. K., Little, S., Kelleher, A., Routy, J.-P., Rosenberg, E. S., Sekaly, R.-P., Walker, B. D., Altfeld, M. (2007). Recognition of a Defined Region within p24 Gag by CD8+ T Cells during Primary Human Immunodeficiency Virus Type 1 Infection in Individuals Expressing Protective HLA Class I Alleles. J. Virol. 81: 7725-7731 [Abstract] [Full Text]  
  • Yang, H., Dong, T., Turnbull, E., Ranasinghe, S., Ondondo, B., Goonetilleke, N., Winstone, N., di Gleria, K., Bowness, P., Conlon, C., Borrow, P., Hanke, T., McMichael, A., Dorrell, L. (2007). Broad TCR Usage in Functional HIV-1-Specific CD8+ T Cell Expansions Driven by Vaccination during Highly Active Antiretroviral Therapy. J. Immunol. 179: 597-606 [Abstract] [Full Text]  
  • Gray, E. S., Moore, P. L., Choge, I. A., Decker, J. M., Bibollet-Ruche, F., Li, H., Leseka, N., Treurnicht, F., Mlisana, K., Shaw, G. M., Karim, S. S. A., Williamson, C., Morris, L., and the CAPRISA 002 Study Team, (2007). Neutralizing Antibody Responses in Acute Human Immunodeficiency Virus Type 1 Subtype C Infection. J. Virol. 81: 6187-6196 [Abstract] [Full Text]  
  • Precopio, M. L., Betts, M. R., Parrino, J., Price, D. A., Gostick, E., Ambrozak, D. R., Asher, T. E., Douek, D. C., Harari, A., Pantaleo, G., Bailer, R., Graham, B. S., Roederer, M., Koup, R. A. (2007). Immunization with vaccinia virus induces polyfunctional and phenotypically distinctive CD8+ T cell responses. JEM 204: 1405-1416 [Abstract] [Full Text]  
  • Critchfield, J. W., Lemongello, D., Walker, D. H., Garcia, J. C., Asmuth, D. M., Pollard, R. B., Shacklett, B. L. (2007). Multifunctional Human Immunodeficiency Virus (HIV) Gag-Specific CD8+ T-Cell Responses in Rectal Mucosa and Peripheral Blood Mononuclear Cells during Chronic HIV Type 1 Infection. J. Virol. 81: 5460-5471 [Abstract] [Full Text]  
  • Connick, E., Mattila, T., Folkvord, J. M., Schlichtemeier, R., Meditz, A. L., Ray, M. G., McCarter, M. D., MaWhinney, S., Hage, A., White, C., Skinner, P. J. (2007). CTL Fail to Accumulate at Sites of HIV-1 Replication in Lymphoid Tissue. J. Immunol. 178: 6975-6983 [Abstract] [Full Text]  


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