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J Virol. 1994 July; 68(7): 4650-4655
Temporal association of cellular immune responses with the initial control of viremia in primary human immunodeficiency virus type 1 syndrome.
R A Koup,
J T Safrit,
Y Cao,
C A Andrews,
G McLeod,
W Borkowsky,
C Farthing and
D D Ho
Aaron Diamond AIDS Research Center, New York University School of Medicine, New York 10016.
ABSTRACT
Virologic and immunologic studies were performed on five patients presenting with primary human immunodeficiency virus type 1 (HIV-1) infection. CD8+ cytotoxic T lymphocyte (CTL) precursors specific for cells expressing antigens of HIV-1 Gag, Pol, and Env were detected at or within 3 weeks of presentation in four of the five patients and were detected in all five patients by 3 to 6 months after presentation. The one patient with an absent initial CTL response had prolonged symptoms, persistent viremia, and low CD4+ T-cell count. Neutralizing antibody activity was absent at the time of presentation in all five patients. These findings suggest that cellular immunity is involved in the initial control of virus replication in primary HIV-1 infection and indicate a role for CTL in protective immunity to HIV-1 in vivo.
J Virol. 1994 July; 68(7): 4650-4655
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Dunham, R., Pagliardini, P., Gordon, S., Sumpter, B., Engram, J., Moanna, A., Paiardini, M., Mandl, J. N., Lawson, B., Garg, S., McClure, H. M., Xu, Y.-X., Ibegbu, C., Easley, K., Katz, N., Pandrea, I., Apetrei, C., Sodora, D. L., Staprans, S. I., Feinberg, M. B., Silvestri, G.
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Betts, M. R., Nason, M. C., West, S. M., De Rosa, S. C., Migueles, S. A., Abraham, J., Lederman, M. M., Benito, J. M., Goepfert, P. A., Connors, M., Roederer, M., Koup, R. A.
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Bailey, J. R., Williams, T. M., Siliciano, R. F., Blankson, J. N.
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(2006). Induction of Multifunctional Human Immunodeficiency Virus Type 1 (HIV-1)-Specific T Cells Capable of Proliferation in Healthy Subjects by Using a Prime-Boost Regimen of DNA- and Modified Vaccinia Virus Ankara-Vectored Vaccines Expressing HIV-1 Gag Coupled to CD8+ T-Cell Epitopes.. J. Virol.
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Pal, R., Venzon, D., Santra, S., Kalyanaraman, V. S., Montefiori, D. C., Hocker, L., Hudacik, L., Rose, N., Nacsa, J., Edghill-Smith, Y., Moniuszko, M., Hel, Z., Belyakov, I. M., Berzofsky, J. A., Parks, R. W., Markham, P. D., Letvin, N. L., Tartaglia, J., Franchini, G.
(2006). Systemic Immunization with an ALVAC-HIV-1/Protein Boost Vaccine Strategy Protects Rhesus Macaques from CD4+ T-Cell Loss and Reduces both Systemic and Mucosal Simian-Human Immunodeficiency Virus SHIVKU2 RNA Levels.. J. Virol.
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Wang, Z., Metcalf, B., Ribeiro, R. M., McClure, H., Kaur, A.
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Quigley, M. F., Abel, K., Zuber, B., Miller, C. J., Sandberg, J. K., Shacklett, B. L.
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Meyer-Olson, D., Brady, K. W., Bartman, M. T., O'Sullivan, K. M., Simons, B. C., Conrad, J. A., Duncan, C. B., Lorey, S., Siddique, A., Draenert, R., Addo, M., Altfeld, M., Rosenberg, E., Allen, T. M., Walker, B. D., Kalams, S. A.
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Lauren, A., Thorstensson, R., Fenyo, E. M.
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Snyder-Cappione, J. E., Divekar, A. A., Maupin, G. M., Jin, X., Demeter, L. M., Mosmann, T. R.
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Someya, K., Ami, Y., Nakasone, T., Izumi, Y., Matsuo, K., Horibata, S., Xin, K.-Q., Yamamoto, H., Okuda, K., Yamamoto, N., Honda, M.
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Elrefaei, M., Barugahare, B., Ssali, F., Mugyenyi, P., Cao, H.
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Newberg, M. H., McEvers, K. J., Gorgone, D. A., Lifton, M. A., Baumeister, S. H. C., Veazey, R. S., Schmitz, J. E., Letvin, N. L.
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Yang, O. O., Church, J., Kitchen, C. M. R., Kilpatrick, R., Ali, A., Geng, Y., Killian, M. S., Sabado, R. L., Ng, H., Suen, J., Bryson, Y., Jamieson, B. D., Krogstad, P.
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Casimiro, D. R., Wang, F., Schleif, W. A., Liang, X., Zhang, Z.-Q., Tobery, T. W., Davies, M.-E., McDermott, A. B., O'Connor, D. H., Fridman, A., Bagchi, A., Tussey, L. G., Bett, A. J., Finnefrock, A. C., Fu, T.-m., Tang, A., Wilson, K. A., Chen, M., Perry, H. C., Heidecker, G. J., Freed, D. C., Carella, A., Punt, K. S., Sykes, K. J., Huang, L., Ausensi, V. I., Bachinsky, M., Sadasivan-Nair, U., Watkins, D. I., Emini, E. A., Shiver, J. W.
(2005). Attenuation of Simian Immunodeficiency Virus SIVmac239 Infection by Prophylactic Immunization with DNA and Recombinant Adenoviral Vaccine Vectors Expressing Gag. J. Virol.
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Mao, H., Lafont, B. A. P., Igarashi, T., Nishimura, Y., Brown, C., Hirsch, V., Buckler-White, A., Sadjadpour, R., Martin, M. A.
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Loffredo, J. T., Rakasz, E. G., Giraldo, J. P., Spencer, S. P., Grafton, K. K., Martin, S. R., Napoe, G., Yant, L. J., Wilson, N. A., Watkins, D. I.
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Milicic, A., Edwards, C. T. T., Hue, S., Fox, J., Brown, H., Pillay, T., Drijfhout, J. W., Weber, J. N., Holmes, E. C., Fidler, S. J., Zhang, H.-T., Phillips, R. E.
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