This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Schuitemaker, H
Right arrow Articles by Tersmette, M
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Schuitemaker, H
Right arrow Articles by Tersmette, M

 Previous Article  |  Next Article 

J Virol. 1992 March; 66(3): 1354-1360

Biological phenotype of human immunodeficiency virus type 1 clones at different stages of infection: progression of disease is associated with a shift from monocytotropic to T-cell-tropic virus population.

H Schuitemaker, M Koot, N A Kootstra, M W Dercksen, R E de Goede, R P van Steenwijk, J M Lange, J K Schattenkerk, F Miedema and M Tersmette

Central Laboratory, Netherlands Red Cross Blood Transfusion Service, Amsterdam.

ABSTRACT

The composition of human immunodeficiency virus type 1 (HIV-1) clonal populations at different stages of infection and in different compartments was analyzed. Biological HIV-1 clones were obtained by primary isolation from patient peripheral blood mononuclear cells under limiting dilution conditions, with either blood donor peripheral blood lymphocytes or monocyte-derived macrophages (MDM) as target cells, and the biological phenotype of the clones was analyzed. In asymptomatic individuals, low frequencies of HIV-1 clones were observed. These clones were non-syncytium inducing and preferentially monocytotropic. In individuals progressing to disease, a 100-fold increase in frequencies of productively HIV-1-infected cells was observed as a result of a selective expansion of nonmonocytotropic clones. In a person progressing to AIDS within 19 months after infection, only syncytium-inducing clones were detected, shifting from MDM-tropic to non-MDM-tropic over time. From his virus donor, a patient with wasting syndrome, only syncytium-inducing clones, mostly non-MDM-tropic, were recovered. Parallel clonal analysis of HIV-1 populations in cells present in bronchoalveolar lavage fluid and peripheral blood from an AIDS patient revealed a qualitatively and quantitatively more monocytotropic virus population in the lung compartment than in peripheral blood at the same time point. These findings indicate that monocytotropic HIV-1 clones, probably generated in the tissues, are responsible for the persistence of HIV-1 infection and that progression of HIV-1 infection is associated with a selective increase of T-cell-tropic, nonmonocytotropic HIV-1 variants in peripheral blood.

J Virol. 1992 March; 66(3): 1354-1360




This article has been cited by other articles:

  • Moreno-Fernandez, M. E., Zapata, W., Blackard, J. T., Franchini, G., Chougnet, C. A. (2009). Human Regulatory T Cells Are Targets for Human Immunodeficiency Virus (HIV) Infection, and Their Susceptibility Differs Depending on the HIV Type 1 Strain. J. Virol. 83: 12925-12933 [Abstract] [Full Text]  
  • Del Prete, G. Q., Haggarty, B., Leslie, G. J., Jordan, A. P. O., Romano, J., Wang, N., Wang, J., Holmes, M. C., Montefiori, D. C., Hoxie, J. A. (2009). Derivation and Characterization of a Simian Immunodeficiency Virus SIVmac239 Variant with Tropism for CXCR4. J. Virol. 83: 9911-9922 [Abstract] [Full Text]  
  • Hosoya, N., Su, Z., Wilkin, T., Gulick, R. M., Flexner, C., Hughes, M. D., Skolnik, P. R., Giguel, F., Greaves, W. L., Coakley, E., Kuritzkes, D. R. (2009). Assessing Human Immunodeficiency Virus Type 1 Tropism: Comparison of Assays Using Replication-Competent Virus versus Plasma-Derived Pseudotyped Virions. J. Clin. Microbiol. 47: 2604-2606 [Abstract] [Full Text]  
  • Nolan, K. M., Del Prete, G. Q., Jordan, A. P. O., Haggarty, B., Romano, J., Leslie, G. J., Hoxie, J. A. (2009). Characterization of a Human Immunodeficiency Virus Type 1 V3 Deletion Mutation That Confers Resistance to CCR5 Inhibitors and the Ability To Use Aplaviroc-Bound Receptor. J. Virol. 83: 3798-3809 [Abstract] [Full Text]  
  • Giri, M. S., Nebozyhn, M., Raymond, A., Gekonge, B., Hancock, A., Creer, S., Nicols, C., Yousef, M., Foulkes, A. S., Mounzer, K., Shull, J., Silvestri, G., Kostman, J., Collman, R. G., Showe, L., Montaner, L. J. (2009). Circulating Monocytes in HIV-1-Infected Viremic Subjects Exhibit an Antiapoptosis Gene Signature and Virus- and Host-Mediated Apoptosis Resistance. J. Immunol. 182: 4459-4470 [Abstract] [Full Text]  
  • Whiteside, T. L., Piazza, P., Reiter, A., Stanson, J., Connolly, N. C., Rinaldo, C. R. Jr., Riddler, S. A. (2009). Production of a Dendritic Cell-Based Vaccine Containing Inactivated Autologous Virus for Therapy of Patients with Chronic Human Immunodeficiency Virus Type 1 Infection. CVI 16: 233-240 [Abstract] [Full Text]  
  • Coetzer, M., Nedellec, R., Salkowitz, J., McLaughlin, S., Liu, Y., Heath, L., Mullins, J. I., Mosier, D. E. (2008). Evolution of CCR5 Use before and during Coreceptor Switching. J. Virol. 82: 11758-11766 [Abstract] [Full Text]  
  • Bunnik, E. M., Pisas, L., van Nuenen, A. C., Schuitemaker, H. (2008). Autologous Neutralizing Humoral Immunity and Evolution of the Viral Envelope in the Course of Subtype B Human Immunodeficiency Virus Type 1 Infection. J. Virol. 82: 7932-7941 [Abstract] [Full Text]  
  • Tasca, S., Ho, S.-H., Cheng-Mayer, C. (2008). R5X4 Viruses Are Evolutionary, Functional, and Antigenic Intermediates in the Pathway of a Simian-Human Immunodeficiency Virus Coreceptor Switch. J. Virol. 82: 7089-7099 [Abstract] [Full Text]  
  • Fransen, S., Bridger, G., Whitcomb, J. M., Toma, J., Stawiski, E., Parkin, N., Petropoulos, C. J., Huang, W. (2008). Suppression of Dualtropic Human Immunodeficiency Virus Type 1 by the CXCR4 Antagonist AMD3100 Is Associated with Efficiency of CXCR4 Use and Baseline Virus Composition. Antimicrob. Agents Chemother. 52: 2608-2615 [Abstract] [Full Text]  
  • Garrido, C., Roulet, V., Chueca, N., Poveda, E., Aguilera, A., Skrabal, K., Zahonero, N., Carlos, S., Garcia, F., Faudon, J. L., Soriano, V., de Mendoza, C. (2008). Evaluation of Eight Different Bioinformatics Tools To Predict Viral Tropism in Different Human Immunodeficiency Virus Type 1 Subtypes. J. Clin. Microbiol. 46: 887-891 [Abstract] [Full Text]  
  • Briz, V., Poveda, E., del Mar Gonzalez, M., Martin-Carbonero, L., Gonzalez-Gonzalez, R., Soriano, V. (2008). Impact of antiretroviral therapy on viral tropism in HIV-infected patients followed longitudinally for over 5 years. J Antimicrob Chemother 61: 405-410 [Abstract] [Full Text]  
  • Nolan, K. M., Jordan, A. P. O., Hoxie, J. A. (2008). Effects of Partial Deletions within the Human Immunodeficiency Virus Type 1 V3 Loop on Coreceptor Tropism and Sensitivity to Entry Inhibitors. J. Virol. 82: 664-673 [Abstract] [Full Text]  
  • Cui, M., Huang, Y., Zhao, Y., Zheng, J. (2008). Transcription Factor FOXO3a Mediates Apoptosis in HIV-1-Infected Macrophages. J. Immunol. 180: 898-906 [Abstract] [Full Text]  
  • DeGottardi, M. Q., Lew, S. K., Piatak, M. Jr., Jia, B., Feng, Y., Lee, S. J., Brenchley, J. M., Douek, D. C., Kodama, T., Lifson, J. D., Evans, D. T. (2008). Comparison of Plasma Viremia and Antibody Responses in Macaques Inoculated with Envelope Variants of Single-Cycle Simian Immunodeficiency Virus Differing in Infectivity and Cellular Tropism. J. Virol. 82: 321-334 [Abstract] [Full Text]  
  • Murphy, S. L., Gaulton, G. N. (2007). TR1.3 Viral Pathogenesis and Syncytium Formation Are Linked to Env-Gag Cooperation. J. Virol. 81: 10777-10785 [Abstract] [Full Text]  
  • Milush, J. M., Reeves, J. D., Gordon, S. N., Zhou, D., Muthukumar, A., Kosub, D. A., Chacko, E., Giavedoni, L. D., Ibegbu, C. C., Cole, K. S., Miamidian, J. L., Paiardini, M., Barry, A. P., Staprans, S. I., Silvestri, G., Sodora, D. L. (2007). Virally Induced CD4+ T Cell Depletion Is Not Sufficient to Induce AIDS in a Natural Host. J. Immunol. 179: 3047-3056 [Abstract] [Full Text]  
  • Quakkelaar, E. D., van Alphen, F. P. J., Boeser-Nunnink, B. D. M., van Nuenen, A. C., Pantophlet, R., Schuitemaker, H. (2007). Susceptibility of Recently Transmitted Subtype B Human Immunodeficiency Virus Type 1 Variants to Broadly Neutralizing Antibodies. J. Virol. 81: 8533-8542 [Abstract] [Full Text]  
  • Delobel, P., Nugeyre, M.-T., Cazabat, M., Pasquier, C., Marchou, B., Massip, P., Barre-Sinoussi, F., Israel, N., Izopet, J. (2007). Population-Based Sequencing of the V3 Region of env for Predicting the Coreceptor Usage of Human Immunodeficiency Virus Type 1 Quasispecies. J. Clin. Microbiol. 45: 1572-1580 [Abstract] [Full Text]  
  • de Mendoza, C., Rodriguez, C., Garcia, F., Eiros, J. M., Ruiz, L., Caballero, E., Aguilera, A., Leiva, P., Colomina, J., Gutierrez, F., del Romero, J., Aguero, J., Soriano, V., on behalf of the Spanish HIV Seroconverter Study G, (2007). Prevalence of X4 tropic viruses in patients recently infected with HIV-1 and lack of association with transmission of drug resistance. J Antimicrob Chemother 59: 698-704 [Abstract] [Full Text]  
  • Kiselyeva, Y., Nedellec, R., Ramos, A., Pastore, C., Margolis, L. B., Mosier, D. E. (2007). Evolution of CXCR4-Using Human Immunodeficiency Virus Type 1 SF162 Is Associated with Two Unique Envelope Mutations. J. Virol. 81: 3657-3661 [Abstract] [Full Text]  
  • Whitcomb, J. M., Huang, W., Fransen, S., Limoli, K., Toma, J., Wrin, T., Chappey, C., Kiss, L. D. B., Paxinos, E. E., Petropoulos, C. J. (2007). Development and Characterization of a Novel Single-Cycle Recombinant-Virus Assay To Determine Human Immunodeficiency Virus Type 1 Coreceptor Tropism. Antimicrob. Agents Chemother. 51: 566-575 [Abstract] [Full Text]  
  • Madani, N., Hubicki, A. M., Perdigoto, A. L., Springer, M., Sodroski, J. (2007). Inhibition of Human Immunodeficiency Virus Envelope Glycoprotein- Mediated Single Cell Lysis by Low-Molecular-Weight Antagonists of Viral Entry. J. Virol. 81: 532-538 [Abstract] [Full Text]  
  • Bunnik, E. M., Quakkelaar, E. D., van Nuenen, A. C., Boeser-Nunnink, B., Schuitemaker, H. (2007). Increased Neutralization Sensitivity of Recently Emerged CXCR4-Using Human Immunodeficiency Virus Type 1 Strains Compared to Coexisting CCR5-Using Variants from the Same Patient. J. Virol. 81: 525-531 [Abstract] [Full Text]  
  • Nishimura, Y., Igarashi, T., Buckler-White, A., Buckler, C., Imamichi, H., Goeken, R. M., Lee, W. R., Lafont, B. A. P., Byrum, R., Lane, H. C., Hirsch, V. M., Martin, M. A. (2007). Loss of Naive Cells Accompanies Memory CD4+ T-Cell Depletion during Long-Term Progression to AIDS in Simian Immunodeficiency Virus-Infected Macaques. J. Virol. 81: 893-902 [Abstract] [Full Text]  
  • Llewellyn, N., Zioni, R., Zhu, H., Andrus, T., Xu, Y., Corey, L., Zhu, T. (2006). Continued evolution of HIV-1 circulating in blood monocytes with antiretroviral therapy: genetic analysis of HIV-1 in monocytes and CD4+ T cells of patients with discontinued therapy.. J. Leukoc. Biol. 80: 1118-1126 [Abstract] [Full Text]  
  • Goodenow, M. M., Collman, R. G. (2006). HIV-1 coreceptor preference is distinct from target cell tropism: a dual-parameter nomenclature to define viral phenotypes. J. Leukoc. Biol. 80: 965-972 [Abstract] [Full Text]  
  • Baenziger, S., Tussiwand, R., Schlaepfer, E., Mazzucchelli, L., Heikenwalder, M., Kurrer, M. O., Behnke, S., Frey, J., Oxenius, A., Joller, H., Aguzzi, A., Manz, M. G., Speck, R. F. (2006). Disseminated and sustained HIV infection in CD34+ cord blood cell-transplanted Rag2-/-{gamma}c-/- mice. Proc. Natl. Acad. Sci. USA 103: 15951-15956 [Abstract] [Full Text]  
  • van den Dool, C., de Boer, R. J. (2006). The Effects of Age, Thymectomy, and HIV Infection on {alpha} and beta TCR Excision Circles in Naive T Cells. J. Immunol. 177: 4391-4401 [Abstract] [Full Text]  
  • Fernandez, G., Llano, A., Esgleas, M., Clotet, B., Este, J. A., Martinez, M. A. (2006). Purifying selection of CCR5-tropic human immunodeficiency virus type 1 variants in AIDS subjects that have developed syncytium-inducing, CXCR4-tropic viruses.. J. Gen. Virol. 87: 1285-1294 [Abstract] [Full Text]  
  • Mendoza, R., Anderson, M. M., Overbaugh, J. (2006). A putative thiamine transport protein is a receptor for feline leukemia virus subgroup a.. J. Virol. 80: 3378-3385 [Abstract] [Full Text]  
  • Pastore, C., Nedellec, R., Ramos, A., Pontow, S., Ratner, L., Mosier, D. E. (2006). Human Immunodeficiency Virus Type 1 Coreceptor Switching: V1/V2 Gain-of-Fitness Mutations Compensate for V3 Loss-of-Fitness Mutations. J. Virol. 80: 750-758 [Abstract] [Full Text]  
  • Montano, M., Rarick, M., Sebastiani, P., Brinkmann, P., Skefos, J., Ericksen, R. (2006). HIV-1 burden influences host response to co-infection with Neisseria gonorrhoeae in vitro. Int Immunol 18: 125-137 [Abstract] [Full Text]  
  • Mack, M., Pfirstinger, J., Haas, J., Nelson, P. J., Kufer, P., Riethmuller, G., Schlondorff, D. (2005). Preferential Targeting of CD4-CCR5 Complexes with Bifunctional Inhibitors: A Novel Approach to Block HIV-1 Infection. J. Immunol. 175: 7586-7593 [Abstract] [Full Text]  
  • Ghaffari, G., Tuttle, D. L., Briggs, D., Burkhardt, B. R., Bhatt, D., Andiman, W. A., Sleasman, J. W., Goodenow, M. M. (2005). Complex Determinants in Human Immunodeficiency Virus Type 1 Envelope gp120 Mediate CXCR4-Dependent Infection of Macrophages. J. Virol. 79: 13250-13261 [Abstract] [Full Text]  
  • Mondal, D., Williams, C. A., Ali, M., Eilers, M., Agrawal, K. C. (2005). The HIV-1 Tat Protein Selectively Enhances CXCR4 and Inhibits CCR5 Expression in Megakaryocytic K562 Cells. Exp. Biol. Med. 230: 631-644 [Abstract] [Full Text]  
  • Skrabal, K., Saragosti, S., Labernardiere, J.-L., Barin, F., Clavel, F., Mammano, F. (2005). Human Immunodeficiency Virus Type 1 Variants Isolated from Single Plasma Samples Display a Wide Spectrum of Neutralization Sensitivity. J. Virol. 79: 11848-11857 [Abstract] [Full Text]  
  • Brown, A., Gartner, S., Kawano, T., Benoit, N., Cheng-Mayer, C. (2005). HLA-A2 down-regulation on primary human macrophages infected with an M-tropic EGFP-tagged HIV-1 reporter virus. J. Leukoc. Biol. 78: 675-685 [Abstract] [Full Text]  
  • Troyer, R. M., Collins, K. R., Abraha, A., Fraundorf, E., Moore, D. M., Krizan, R. W., Toossi, Z., Colebunders, R. L., Jensen, M. A., Mullins, J. I., Vanham, G., Arts, E. J. (2005). Changes in Human Immunodeficiency Virus Type 1 Fitness and Genetic Diversity during Disease Progression. J. Virol. 79: 9006-9018 [Abstract] [Full Text]  
  • Joos, B., Trkola, A., Fischer, M., Kuster, H., Rusert, P., Leemann, C., Boni, J., Oxenius, A., Price, D. A., Phillips, R. E., Wong, J. K., Hirschel, B., Weber, R., Gunthard, H. F., the Swiss HIV Cohort Study, (2005). Low Human Immunodeficiency Virus Envelope Diversity Correlates with Low In Vitro Replication Capacity and Predicts Spontaneous Control of Plasma Viremia after Treatment Interruptions. J. Virol. 79: 9026-9037 [Abstract] [Full Text]  
  • Platt, E. J., Durnin, J. P., Kabat, D. (2005). Kinetic Factors Control Efficiencies of Cell Entry, Efficacies of Entry Inhibitors, and Mechanisms of Adaptation of Human Immunodeficiency Virus. J. Virol. 79: 4347-4356 [Abstract] [Full Text]  
  • Williamson, S., Perry, S. M., Bustamante, C. D., Orive, M. E., Stearns, M. N., Kelly, J. K. (2005). A Statistical Characterization of Consistent Patterns of Human Immunodeficiency Virus Evolution Within Infected Patients. Mol Biol Evol 22: 456-468 [Abstract] [Full Text]  
  • Yi, Y., Shaheen, F., Collman, R. G. (2005). Preferential Use of CXCR4 by R5X4 Human Immunodeficiency Virus Type 1 Isolates for Infection of Primary Lymphocytes. J. Virol. 79: 1480-1486 [Abstract] [Full Text]  
  • Ribeiro, A. C., Maia e Silva, A., Santa-Marta, M., Pombo, A., Moniz-Pereira, J., Goncalves, J., Barahona, I. (2005). Functional Analysis of Vif Protein Shows Less Restriction of Human Immunodeficiency Virus Type 2 by APOBEC3G. J. Virol. 79: 823-833 [Abstract] [Full Text]  
  • Choudhary, S. K., Choudhary, N. R., Kimbrell, K. C., Colasanti, J., Ziogas, A., Kwa, D., Schuitemaker, H., Camerini, D. (2005). R5 Human Immunodeficiency Virus Type 1 Infection of Fetal Thymic Organ Culture Induces Cytokine and CCR5 Expression. J. Virol. 79: 458-471 [Abstract] [Full Text]  
  • Princen, K., Hatse, S., Vermeire, K., Aquaro, S., De Clercq, E., Gerlach, L.-O., Rosenkilde, M., Schwartz, T. W., Skerlj, R., Bridger, G., Schols, D. (2004). Inhibition of Human Immunodeficiency Virus Replication by a Dual CCR5/CXCR4 Antagonist. J. Virol. 78: 12996-13006 [Abstract] [Full Text]  
  • Owen, A., Chandler, B., Bray, P. G., Ward, S. A., Hart, C. A., Back, D. J., Khoo, S. H. (2004). Functional Correlation of P-Glycoprotein Expression and Genotype with Expression of the Human Immunodeficiency Virus Type 1 Coreceptor CXCR4. J. Virol. 78: 12022-12029 [Abstract] [Full Text]  
  • Schweighardt, B., Roy, A.-M., Meiklejohn, D. A., Grace, E. J. II, Moretto, W. J., Heymann, J. J., Nixon, D. F. (2004). R5 Human Immunodeficiency Virus Type 1 (HIV-1) Replicates More Efficiently in Primary CD4+ T-Cell Cultures Than X4 HIV-1. J. Virol. 78: 9164-9173 [Abstract] [Full Text]  
  • Nishimura, Y., Igarashi, T., Donau, O. K., Buckler-White, A., Buckler, C., Lafont, B. A. P., Goeken, R. M., Goldstein, S., Hirsch, V. M., Martin, M. A. (2004). Highly pathogenic SHIVs and SIVs target different CD4+ T cell subsets in rhesus monkeys, explaining their divergent clinical courses. Proc. Natl. Acad. Sci. USA 101: 12324-12329 [Abstract] [Full Text]  
  • Fulcher, J. A., Hwangbo, Y., Zioni, R., Nickle, D., Lin, X., Heath, L., Mullins, J. I., Corey, L., Zhu, T. (2004). Compartmentalization of Human Immunodeficiency Virus Type 1 between Blood Monocytes and CD4+ T Cells during Infection. J. Virol. 78: 7883-7893 [Abstract] [Full Text]  
  • Pastore, C., Ramos, A., Mosier, D. E. (2004). Intrinsic Obstacles to Human Immunodeficiency Virus Type 1 Coreceptor Switching. J. Virol. 78: 7565-7574 [Abstract] [Full Text]  
  • Fitzgerald, W., Sylwester, A. W., Grivel, J.-C., Lifson, J. D., Margolis, L. B. (2004). Noninfectious X4 but Not R5 Human Immunodeficiency Virus Type 1 Virions Inhibit Humoral Immune Responses in Human Lymphoid Tissue Ex Vivo. J. Virol. 78: 7061-7068 [Abstract] [Full Text]  
  • Beaumont, T., Quakkelaar, E., van Nuenen, A., Pantophlet, R., Schuitemaker, H. (2004). Increased Sensitivity to CD4 Binding Site-Directed Neutralization following In Vitro Propagation on Primary Lymphocytes of a Neutralization-Resistant Human Immunodeficiency Virus IIIB Strain Isolated from an Accidentally Infected Laboratory Worker. J. Virol. 78: 5651-5657 [Abstract] [Full Text]  
  • Brainard, D. M., Tharp, W. G., Granado, E., Miller, N., Trocha, A. K., Ren, X.-H., Conrad, B., Terwilliger, E. F., Wyatt, R., Walker, B. D., Poznansky, M. C. (2004). Migration of Antigen-Specific T Cells Away from CXCR4-Binding Human Immunodeficiency Virus Type 1 gp120. J. Virol. 78: 5184-5193 [Abstract] [Full Text]  
  • Giri, M., Ugen, K. E., Weiner, D. B. (2004). DNA Vaccines against Human Immunodeficiency Virus Type 1 in the Past Decade. Clin. Microbiol. Rev. 17: 370-389 [Abstract] [Full Text]  
  • Stalmeijer, E. H. B., van Rij, R. P., Boeser-Nunnink, B., Visser, J. A., Naarding, M. A., Schols, D., Schuitemaker, H. (2004). In Vivo Evolution of X4 Human Immunodeficiency Virus Type 1 Variants in the Natural Course of Infection Coincides with Decreasing Sensitivity to CXCR4 Antagonists. J. Virol. 78: 2722-2728 [Abstract] [Full Text]  
  • Pollakis, G., Abebe, A., Kliphuis, A., Chalaby, M. I. M., Bakker, M., Mengistu, Y., Brouwer, M., Goudsmit, J., Schuitemaker, H., Paxton, W. A. (2004). Phenotypic and Genotypic Comparisons of CCR5- and CXCR4-Tropic Human Immunodeficiency Virus Type 1 Biological Clones Isolated from Subtype C-Infected Individuals. J. Virol. 78: 2841-2852 [Abstract] [Full Text]  
  • Audige, A., Schlaepfer, E., Bonanomi, A., Joller, H., Knuchel, M. C., Weber, M., Nadal, D., Speck, R. F. (2004). HIV-1 Does Not Provoke Alteration of Cytokine Gene Expression in Lymphoid Tissue after Acute Infection Ex Vivo. J. Immunol. 172: 2687-2696 [Abstract] [Full Text]  
  • Ranjbar, S., Ly, N., Thim, S., Reynes, J.-M., Goldfeld, A. E. (2004). Mycobacterium tuberculosis Recall Antigens Suppress HIV-1 Replication in Anergic Donor Cells via CD8+ T Cell Expansion and Increased IL-10 Levels. J. Immunol. 172: 1953-1959 [Abstract] [Full Text]  
  • Nabatov, A. A., Pollakis, G., Linnemann, T., Kliphius, A., Chalaby, M. I. M., Paxton, W. A. (2004). Intrapatient Alterations in the Human Immunodeficiency Virus Type 1 gp120 V1V2 and V3 Regions Differentially Modulate Coreceptor Usage, Virus Inhibition by CC/CXC Chemokines, Soluble CD4, and the b12 and 2G12 Monoclonal Antibodies. J. Virol. 78: 524-530 [Abstract] [Full Text]  
  • Shalekoff, S., Gray, G. E., Tiemessen, C. T. (2004). Age-Related Changes in Expression of CXCR4 and CCR5 on Peripheral Blood Leukocytes from Uninfected Infants Born to Human Immunodeficiency Virus Type 1-Infected Mothers. CVI 11: 229-234 [Abstract] [Full Text]  
  • Igarashi, T., Donau, O. K., Imamichi, H., Dumaurier, M.-J., Sadjadpour, R., Plishka, R. J., Buckler-White, A., Buckler, C., Suffredini, A. F., Lane, H. C., Moore, J. P., Martin, M. A. (2003). Macrophage-Tropic Simian/Human Immunodeficiency Virus Chimeras Use CXCR4, Not CCR5, for Infections of Rhesus Macaque Peripheral Blood Mononuclear Cells and Alveolar Macrophages. J. Virol. 77: 13042-13052 [Abstract] [Full Text]  
  • Trkola, A., Kuster, H., Leemann, C., Ruprecht, C., Joos, B., Telenti, A., Hirschel, B., Weber, R., Bonhoeffer, S., Gunthard, H. F. (2003). Human Immunodeficiency Virus Type 1 Fitness Is a Determining Factor in Viral Rebound and Set Point in Chronic Infection. J. Virol. 77: 13146-13155 [Abstract] [Full Text]  
  • Vogel, T. U., Reynolds, M. R., Fuller, D. H., Vielhuber, K., Shipley, T., Fuller, J. T., Kunstman, K. J., Sutter, G., Marthas, M. L., Erfle, V., Wolinsky, S. M., Wang, C., Allison, D. B., Rud, E. W., Wilson, N., Montefiori, D., Altman, J. D., Watkins, D. I. (2003). Multispecific Vaccine-Induced Mucosal Cytotoxic T Lymphocytes Reduce Acute-Phase Viral Replication but Fail in Long-Term Control of Simian Immunodeficiency Virus SIVmac239. J. Virol. 77: 13348-13360 [Abstract] [Full Text]  
  • Goodenow, M. M., Rose, S. L., Tuttle, D. L., Sleasman, J. W. (2003). HIV-1 fitness and macrophages. J. Leukoc. Biol. 74: 657-666 [Abstract] [Full Text]  
  • Harouse, J. M., Buckner, C., Gettie, A., Fuller, R., Bohm, R., Blanchard, J., Cheng-Mayer, C. (2003). CD8+ T cell-mediated CXC chemokine receptor 4-simian/human immunodeficiency virus suppression in dually infected rhesus macaques. Proc. Natl. Acad. Sci. USA 100: 10977-10982 [Abstract] [Full Text]  
  • Johnston, E. R., Zijenah, L. S., Mutetwa, S., Kantor, R., Kittinunvorakoon, C., Katzenstein, D. A. (2003). High Frequency of Syncytium-Inducing and CXCR4-Tropic Viruses among Human Immunodeficiency Virus Type 1 Subtype C-Infected Patients Receiving Antiretroviral Treatment. J. Virol. 77: 7682-7688 [Abstract] [Full Text]  
  • LaBonte, J. A., Madani, N., Sodroski, J. (2003). Cytolysis by CCR5-Using Human Immunodeficiency Virus Type 1 Envelope Glycoproteins Is Dependent on Membrane Fusion and Can Be Inhibited by High Levels of CD4 Expression. J. Virol. 77: 6645-6659 [Abstract] [Full Text]  
  • Schmitt, N., Chene, L., Boutolleau, D., Nugeyre, M.-T., Guillemard, E., Versmisse, P., Jacquemot, C., Barre-Sinoussi, F., Israel, N. (2003). Positive Regulation of CXCR4 Expression and Signaling by Interleukin-7 in CD4+ Mature Thymocytes Correlates with Their Capacity To Favor Human Immunodeficiency X4 Virus Replication. J. Virol. 77: 5784-5793 [Abstract] [Full Text]  
  • Jekle, A., Keppler, O. T., De Clercq, E., Schols, D., Weinstein, M., Goldsmith, M. A. (2003). In Vivo Evolution of Human Immunodeficiency Virus Type 1 toward Increased Pathogenicity through CXCR4-Mediated Killing of Uninfected CD4 T Cells. J. Virol. 77: 5846-5854 [Abstract] [Full Text]  
  • Ito, Y., Grivel, J.-C., Margolis, L. (2003). Real-Time PCR Assay of Individual Human Immunodeficiency Virus Type 1 Variants in Coinfected Human Lymphoid Tissues. J. Clin. Microbiol. 41: 2126-2131 [Abstract] [Full Text]  
  • Heredia, A., Davis, C., Amoroso, A., Dominique, J. K., Le, N., Klingebiel, E., Reardon, E., Zella, D., Redfield, R. R. (2003). Induction of G1 cycle arrest in T lymphocytes results in increased extracellular levels of beta -chemokines: A strategy to inhibit R5 HIV-1. Proc. Natl. Acad. Sci. USA 100: 4179-4184 [Abstract] [Full Text]  
  • Olivetta, E., Percario, Z., Fiorucci, G., Mattia, G., Schiavoni, I., Dennis, C., Jager, J., Harris, M., Romeo, G., Affabris, E., Federico, M. (2003). HIV-1 Nef Induces the Release of Inflammatory Factors from Human Monocyte/Macrophages: Involvement of Nef Endocytotic Signals and NF-{kappa}B Activation. J. Immunol. 170: 1716-1727 [Abstract] [Full Text]  
  • Babcock, G. J., Farzan, M., Sodroski, J. (2003). Ligand-independent Dimerization of CXCR4, a Principal HIV-1 Coreceptor. J. Biol. Chem. 278: 3378-3385 [Abstract] [Full Text]  
  • Qin, X.-F., An, D. S., Chen, I. S. Y., Baltimore, D. (2003). Inhibiting HIV-1 infection in human T cells by lentiviral-mediated delivery of small interfering RNA against CCR5. Proc. Natl. Acad. Sci. USA 100: 183-188 [Abstract] [Full Text]  
  • Hsu, M., Harouse, J. M., Gettie, A., Buckner, C., Blanchard, J., Cheng-Mayer, C. (2002). Increased Mucosal Transmission but Not Enhanced Pathogenicity of the CCR5-Tropic, Simian AIDS-Inducing Simian/Human Immunodeficiency Virus SHIVSF162P3 Maps to Envelope gp120. J. Virol. 77: 989-998 [Abstract] [Full Text]  
  • Basmaciogullari, S., Babcock, G. J., Van Ryk, D., Wojtowicz, W., Sodroski, J. (2002). Identification of Conserved and Variable Structures in the Human Immunodeficiency Virus gp120 Glycoprotein of Importance for CXCR4 Binding. J. Virol. 76: 10791-10800 [Abstract] [Full Text]  
  • Fuller, C. L., Choi, Y. K., Fallert, B. A., Capuano, S. III, Rajakumar, P., Murphey-Corb, M., Reinhart, T. A. (2002). Restricted SIV Replication in Rhesus Macaque Lung Tissues During the Acute Phase of Infection. Am. J. Pathol. 161: 969-978 [Abstract] [Full Text]  
  • Zhang, L., Rowe, L., He, T., Chung, C., Yu, J., Yu, W., Talal, A., Markowitz, M., Ho, D. D. (2002). Compartmentalization of Surface Envelope Glycoprotein of Human Immunodeficiency Virus Type 1 during Acute and Chronic Infection. J. Virol. 76: 9465-9473 [Abstract] [Full Text]  
  • Jekle, A., Schramm, B., Jayakumar, P., Trautner, V., Schols, D., De Clercq, E., Mills, J., Crowe, S. M., Goldsmith, M. A. (2002). Coreceptor Phenotype of Natural Human Immunodeficiency Virus with Nef Deleted Evolves In Vivo, Leading to Increased Virulence. J. Virol. 76: 6966-6973 [Abstract] [Full Text]  
  • Kijak, G. H., Simon, V., Balfe, P., Vanderhoeven, J., Pampuro, S. E., Zala, C., Ochoa, C., Cahn, P., Markowitz, M., Salomon, H. (2002). Origin of Human Immunodeficiency Virus Type 1 Quasispecies Emerging after Antiretroviral Treatment Interruption in Patients with Therapeutic Failure. J. Virol. 76: 7000-7009 [Abstract] [Full Text]  
  • Patel, P. G., Yu Kimata, M. T., Biggins, J. E., Wilson, J. M., Kimata, J. T. (2002). Highly Pathogenic Simian Immunodeficiency Virus mne Variants That Emerge during the Course of Infection Evolve Enhanced Infectivity and the Ability To Downregulate CD4 but Not Class I Major Histocompatibility Complex Antigens. J. Virol. 76: 6425-6434 [Abstract] [Full Text]  
  • Zheng, N. N., Vella, C., Easterbrook, P. J., Daniels, R. S. (2002). Selection following isolation of human immunodeficiency virus type 1 in peripheral blood mononuclear cells and herpesvirus saimiri-transformed T cells is comparable. J. Gen. Virol. 83: 1343-1352 [Abstract] [Full Text]  
  • Hoffman, N. G., Seillier-Moiseiwitsch, F., Ahn, J., Walker, J. M., Swanstrom, R. (2002). Variability in the Human Immunodeficiency Virus Type 1 gp120 Env Protein Linked to Phenotype-Associated Changes in the V3 Loop. J. Virol. 76: 3852-3864 [Abstract] [Full Text]  
  • CRISTILLO, A. D., HIGHBARGER, H. C., DEWAR, R. L., DIMITROV, D. S., GOLDING, H., BIERER, B. E. (2002). Up-regulation of HIV coreceptor CXCR4 expression in human T lymphocytes is mediated in part by a cAMP-responsive element. FASEB J. 16: 354-364 [Abstract] [Full Text]  
  • Zhao, X.-Q., Huang, X.-L., Gupta, P., Borowski, L., Fan, Z., Watkins, S. C., Thomas, E. K., Rinaldo, C. R. Jr. (2002). Induction of Anti-Human Immunodeficiency Virus Type 1 (HIV-1) CD8+ and CD4+ T-Cell Reactivity by Dendritic Cells Loaded with HIV-1 X4-Infected Apoptotic Cells. J. Virol. 76: 3007-3014 [Abstract] [Full Text]  
  • Suzuki, J.-i., Miyano-Kurosaki, N., Kuwasaki, T., Takeuchi, H., Kawai, G., Takaku, H. (2002). Inhibition of Human Immunodeficiency Virus Type 1 Activity In Vitro by a New Self-Stabilized Oligonucleotide with Guanosine-Thymidine Quadruplex Motifs. J. Virol. 76: 3015-3022 [Abstract] [Full Text]  
  • Bounou, S., Leclerc, J. E., Tremblay, M. J. (2002). Presence of Host ICAM-1 in Laboratory and Clinical Strains of Human Immunodeficiency Virus Type 1 Increases Virus Infectivity and CD4+-T-Cell Depletion in Human Lymphoid Tissue, a Major Site of Replication In Vivo. J. Virol. 76: 1004-1014 [Abstract] [Full Text]  
  • Curran, R., Jameson, C. L., Craggs, J. K., Grabowska, A. M., Thomson, B. J., Robins, A., Irving, W. L., Ball, J. K. (2002). Evolutionary trends of the first hypervariable region of the hepatitis C virus E2 protein in individuals with differing liver disease severity. J. Gen. Virol. 83: 11-23 [Abstract] [Full Text]  
  • Platt, E. J., Kuhmann, S. E., Rose, P. P., Kabat, D. (2001). Adaptive Mutations in the V3 Loop of gp120 Enhance Fusogenicity of Human Immunodeficiency Virus Type 1 and Enable Use of a CCR5 Coreceptor That Lacks the Amino-Terminal Sulfated Region. J. Virol. 75: 12266-12278 [Abstract] [Full Text]  
  • Tanaka, R., Yoshida, A., Murakami, T., Baba, E., Lichtenfeld, J., Omori, T., Kimura, T., Tsurutani, N., Fujii, N., Wang, Z.-X., Peiper, S. C., Yamamoto, N., Tanaka, Y. (2001). Unique Monoclonal Antibody Recognizing the Third Extracellular Loop of CXCR4 Induces Lymphocyte Agglutination and Enhances Human Immunodeficiency Virus Type 1-Mediated Syncytium Formation and Productive Infection. J. Virol. 75: 11534-11543 [Abstract] [Full Text]  
  • Kwa, D., Vingerhoed, J., Boeser-Nunnink, B., Broersen, S., Schuitemaker, H. (2001). Cytopathic Effects of Non-Syncytium-Inducing and Syncytium-Inducing Human Immunodeficiency Virus Type 1 Variants on Different CD4+-T-Cell Subsets Are Determined Only by Coreceptor Expression. J. Virol. 75: 10455-10459 [Abstract] [Full Text]  
  • Malkevich, N., Womack, C., Pandya, P., Grivel, J.-C., Fauci, A. S., Margolis, L. (2001). Human Immunodeficiency Virus Type 1 (HIV-1) Non-B Subtypes Are Similar to HIV-1 Subtype B in that Coreceptor Specificity Is a Determinant of Cytopathicity in Human Lymphoid Tissue Infected Ex Vivo. J. Virol. 75: 10520-10522 [Abstract] [Full Text]  
  • Federico, M., Percario, Z., Olivetta, E., Fiorucci, G., Muratori, C., Micheli, A., Romeo, G., Affabris, E. (2001). HIV-1 Nef activates STAT1 in human monocytes/macrophages through the release of soluble factors. Blood 98: 2752-2761 [Abstract] [Full Text]  
  • Kreisberg, J. F., Kwa, D., Schramm, B., Trautner, V., Connor, R., Schuitemaker, H., Mullins, J. I., van't Wout, A. B., Goldsmith, M. A. (2001). Cytopathicity of Human Immunodeficiency Virus Type 1 Primary Isolates Depends on Coreceptor Usage and Not Patient Disease Status. J. Virol. 75: 8842-8847 [Abstract] [Full Text]  
  • Koning, F. A., Schols, D., Schuitemaker, H. (2001). No Selection for CCR5 Coreceptor Usage during Parenteral Transmission of Macrophagetropic Syncytium-Inducing Human Immunodeficiency Virus Type 1. J. Virol. 75: 8848-8853 [Abstract] [Full Text]  
  • Tokunaga, K., Greenberg, M. L., Morse, M. A., Cumming, R. I., Lyerly, H. K., Cullen, B. R. (2001). Molecular Basis for Cell Tropism of CXCR4-Dependent Human Immunodeficiency Virus Type 1 Isolates. J. Virol. 75: 6776-6785 [Abstract] [Full Text]  
  • Lane, B. R., Strieter, R. M., Coffey, M. J., Markovitz, D. M. (2001). Human Immunodeficiency Virus Type 1 (HIV-1)-Induced GRO-{alpha} Production Stimulates HIV-1 Replication in Macrophages and T Lymphocytes. J. Virol. 75: 5812-5822 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»